Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients

Mediators of Inflammation
Agnieszka ŻyłkaMarek Kuźniewski

Abstract

Diabetic kidney disease develops in half of genetically predisposed patients with type 2 diabetes (T2DM). Early diagnosis of kidney damage and nephroprotective treatment are the ways of preventing the disease progression. Our aim was to evaluate selected laboratory markers of glomerular and tubular damage in T2DM patients with early stages of chronic kidney disease (G1/G2, A1/A2) for their associations with A2 albuminuria and early decline in the estimated glomerular filtration rate (eGFR). Among 80 T2DM patients with median eGFR of 92.4 ml/min/1.73 m2 and median urinary albumin to creatinine ratio (uACR) of 4.69 mg/g, 19 had uACR > 30 mg/g (A2). Higher serum cystatin C, serum and urine neutrophil gelatinase associated lipocalin (NGAL), urine kidney injury molecule 1 (KIM-1), detectable urine transferrin and IgG, and lower serum uromodulin significantly predicted A2 albuminuria, urine KIM-1/creatinine ratio, and IgG being the best predictors. Albuminuria, urine NGAL/creatinine, and IgG correlated with diabetes duration. Albuminuria, urine NGAL, transferrin, IgG, and uromodulin correlated with diabetes control. In a subgroup of 29 patients, retrospective data were available on changes in eGFR and uACR over one year. Decline in e...Continue Reading

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Citations

Jul 18, 2019·International Journal of Molecular Sciences·Francesca BonominiRita Rezzani
Dec 24, 2019·American Journal of Physiology. Renal Physiology·Veronica DimuccioBenedetta Bussolati
Oct 31, 2019·International Journal of Molecular Sciences·Chia-Jung ChangAkiyoshi Taniguchi
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Jan 13, 2021·Environmental Science and Pollution Research International·Rogelio Flores-RamírezLorena Díaz de León-Martínez
Dec 31, 2020·International Journal of Molecular Sciences·Irina LousaAlice Santos-Silva
Nov 27, 2019·Molecular Metabolism·Haiyan FuDong Zhou
Sep 28, 2021·Frontiers in Medicine·Babak YazdaniMarcus E Kleber
Feb 3, 2020·Kidney & Blood Pressure Research·Fatemeh AbbasiAlireza Esteghamati

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Methods Mentioned

BETA
biopsy
ELISA

Software Mentioned

Statistica

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