Markers of gluten intolerance in children with autism spectrum disorders and Down'syndrome

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
I A BavykinaT L Nastausheva

Abstract

To study serological and genetic markers of gluten intolerance in children and teenagers with autism spectrum disorders (ASD) and Down's syndrome (DS). Thirty-three children with ASD (group 1) and 8 with DS (group 2), aged from 2.5 to 15 years, were examined. There were 27 boys and 6 girls in group1, 5 boys and 3 girls in group 2. Most of the children were on a regular diet and only 4 children with ASD kept gluten-free diet (GFD). Using ELI method antibodies to gliadin IgG (AntiGliadin IgG), antibodies to deamidated peptides of gliadin IgA (AntiDGP IgA), immunoglobulin A (IgA) were identified. Haplotypes HLA-DQ2 and DQ8 were determined using PCR. AntiGliadin IgG were identified in 12.1% (4) patients of group 1, with the exception of patients on GFD in 13.8%, and in 50% patients of group 2. One child with ASD had selective IgA deficiency. Haplotypes predisposing to celiac disease had 41.9% of patients of group 1 and 37.5% of patients of group 2. In ASD, the distribution of genotypes was as follows: DQ2 (64.3%), DQ8 (28.6%), DQ2/DQ8 (7.1%,). In DS, all patients had haplotype DQ2. AntiDGP IgA were not identified in both groups. The predominant form of gluten intolerance in children with ASD and DS is sensitivity to gluten, which c...Continue Reading

References

Oct 26, 1999·European Neurology·L LuostarinenP Collin
Oct 1, 2008·Annals of Neurology·Marios HadjivassiliouDaniel Aeschlimann
Dec 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·S HusbyUNKNOWN European Society for Pediatric Gastroenterology, Hepatology, and Nutrition
Aug 12, 2015·Nature Reviews. Gastroenterology & Hepatology·Daniel A LefflerAlessio Fasano

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Citations

Aug 6, 2020·International Journal of Molecular Sciences·Mahesh MohanKarol Sestak

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