Markers of hemostatic system activation during treatment of deep vein thrombosis with subcutaneous unfractionated or low-molecular weight heparin

Thrombosis Research
Polona PeternelMojca Stegnar

Abstract

Prothrombin fragments (F1+2), thrombin-antithrombin complexes (TAT) and D-dimers, markers of hemostatic system activation, were measured in 59 consecutive patients with deep vein thrombosis (DVT). Patients were randomly treated either with subcutaneous unfractionated heparin (UH) administered in two to three subcutaneous doses adjusted to activated partial thromboplastin time (APTT) or with low-molecular weight heparin (LMWH) (dalteparin) administered in a fixed dose of 200 IU/kg body weight in one subcutaneous injection daily. Before treatment, F1+2, TAT and D-dimer were above the cut-off level in 27/59 (46%), 34/59 (58%) and all (100%) patients, respectively. Significant associations were observed between F1+2 and TAT (r=.66, P<.001), TAT and D-dimer (r=.36, P<.005) and F1+2 and D-dimer (r=.30, P<.050). On the third day of treatment, F1+2 and TAT significantly decreased to reference values in almost all patients (in 64/66 determinations of both F1+2 and TAT) and remained low on the seventh day of treatment. Compared to pretreatment values, a nonsignificant decrease of D-dimer was noted in both groups, but all values remained above the cut-off value. When markers of hemostatic system activation in the UH and LMWH groups were c...Continue Reading

References

Jul 1, 1997·QJM : Monthly Journal of the Association of Physicians·H BounameauxM J Miron

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Citations

Aug 29, 2009·European Journal of Internal Medicine·E BruinstroopM V Huisman
Nov 10, 2005·Critical Care : the Official Journal of the Critical Care Forum·Stefan JochbergerMartin W Dünser
Feb 15, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Craig P McFarland, Stuart E Lind
Nov 9, 2010·Clinical Orthopaedics and Related Research·Edwin P SuNigel E Sharrock
Feb 15, 2017·The Cochrane Database of Systematic Reviews·Lindsay Robertson, James Strachan
Jul 18, 2020·Circulation. Cardiovascular Interventions·Guillaume DuthoitGilles Montalescot
Jul 18, 2020·Circulation. Cardiovascular Interventions·Derek S Chew, Jonathan P Piccini
Aug 26, 2018·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Johanne SilvainUNKNOWN ATOLL Investigators

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