Markers of inflammation in bacterial diarrhea among travelers, with a focus on enteroaggregative Escherichia coli pathogenicity

The Journal of Infectious Diseases
David E GreenbergH L DuPont

Abstract

The intestinal inflammatory response of traveler's diarrhea acquired in Goa, India, and Guadalajara, Mexico, was studied. Fecal lactoferrin was found in stool samples in which enteroaggregative Escherichia coli (EAEC), enterotoxigenic E. coli, or Salmonella or Shigella species were isolated, with Shigella-positive cases showing the highest level. Samples from cases of Shigella-associated diarrhea had the highest concentrations of fecal cytokines. Travelers to India who had EAEC-associated diarrhea showed elevated levels of interleukin (IL)-8 (median, 341.15 pg/mL) and IL-1beta (median, 749.90 pg/mL). Although 15 travelers to Mexico who had EAEC-associated diarrhea had a median concentration of 0 pg/mL for both IL-8 and IL-1beta, 2 had high levels of IL-8 (1853 and 11,786 pg/mL), and 5 showed elevated levels of IL-1beta (1-1240 pg/mL). Samples from patients in India who had pathogen-negative diarrhea or from patients in Mexico who had asymptomatic EAEC infection were negative for cytokines. Bacterial pathogens causing traveler's diarrhea commonly produce intestinal inflammation, although a subset of patients with EAEC-associated diarrhea fail to develop an inflammatory response.

Citations

Sep 19, 2008·Current Gastroenterology Reports·Miguel M Cabada, A Clinton White
Mar 17, 2004·Current Infectious Disease Reports·David B. HuangHerbert L. DuPont
Jan 21, 2006·Current Treatment Options in Gastroenterology·Andrew W DuPont, Herbert L DuPont
Mar 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jamal A MohamedPablo C Okhuysen
Jul 19, 2006·Clinical Microbiology Reviews·David J Diemert
Oct 3, 2012·Infection and Immunity·Xiaogang Wang, Philip R Hardwidge
Feb 18, 2011·Journal of Clinical Microbiology·Erik H MercadoThomas G Cleary
Dec 6, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Dominique Legrand
Apr 3, 2008·The Journal of Clinical Investigation·William A PetriRichard L Guerrant
Mar 30, 2010·The American Journal of Tropical Medicine and Hygiene·Kristine M PetersonWilliam A Petri
Oct 5, 2010·The American Journal of Tropical Medicine and Hygiene·Japheth A OpintanRichard L Guerrant
Jun 4, 2014·Current Tropical Medicine Reports·Teresa Estrada-GarciaMussaret B Zaidi
Mar 19, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fabio MiyajimaMunir Pirmohamed
Jul 10, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zhi-Dong JiangHerbert L DuPont
Aug 2, 2006·Gastroenterology Clinics of North America·Herbert L DuPont
Oct 21, 2004·Seminars in Pediatric Infectious Diseases·David B Huang, Herbert L Dupont
Jul 17, 2015·Clinical and Experimental Immunology·K L NewmanJ S Leon
Feb 11, 2005·Infectious Disease Clinics of North America·David R Shlim
Mar 20, 2010·Interdisciplinary Perspectives on Infectious Diseases·P KaurA Asea
Jul 11, 2012·FEMS Immunology and Medical Microbiology·Teresa Estrada-Garcia, Fernando Navarro-Garcia
May 18, 2013·Gut Microbes·Casandra W PhilipsonRaquel Hontecillas
Oct 19, 2012·Cell Adhesion & Migration·Erik J Boll, Beth A McCormick
Feb 18, 2011·Gut Microbes·William E BennettPhillip I Tarr
Feb 3, 2006·FEMS Microbiology Letters·Susan M HarringtonJames P Nataro
Jun 25, 2016·Microbial Pathogenesis·Deepika GuptaAnuradha Chakraborti
Sep 15, 2017·Journal of Pediatric Gastroenterology and Nutrition·Aldo A M LimaRichard L Guerrant
Aug 28, 2004·The American Journal of Gastroenterology·Pablo C OkhuysenHerbert L DuPont
Jul 2, 2014·Clinical Microbiology Reviews·Betina Hebbelstrup JensenAndreas Munk Petersen
Apr 1, 2006·The American Journal of Gastroenterology·Zhi-Dong JiangMark LaRocco
Sep 9, 2005·Current Opinion in Infectious Diseases·Herbert L DuPont

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.