Markers of inflammation in men with small abdominal aortic aneurysm

Journal of Vascular Surgery
Duncan J ParryD Julian A Scott

Abstract

Markers of inflammation and fibrin turnover are elevated in individuals with a large (>55 mm) abdominal aortic aneurysm (AAA). Fibrin degradation generates D-dimer, known to possess multiple proinflammatory effects, and levels are elevated during early AAA development. This study characterized the plasma inflammatory response during early AAA pathogenesis to determine the effect of D-dimer levels. The study compared 75 men with a small AAA (range, 30-54 mm) with 90 age-, sex-, and race-matched controls. Plasma interleukin-6 (IL-6), complement C3, high-sensitivity C-reactive protein (hsCRP), fibrinogen, and D-dimer levels were measured. Mean levels of fibrinogen (2.92 vs 2.59 g/L; P = .003), hsCRP (2.07 vs 1.29 ng/mL; P = .005), and D-dimer (346.7 vs 120.2 ng/mL; P < .001) were higher in men with a small AAA. These markers correlated with maximum aortic diameter determined by ultrasound imaging. On multivariate analysis, D-dimer levels were elevated in AAA individuals independent of smoking, cardiovascular disease (CVD), atherosclerotic risk factors, and inflammatory parameters. Fibrinogen and hsCRP levels remained elevated after adjustment for these covariates but lost significance when D-dimer was added to the model. C-reactiv...Continue Reading

References

Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D G RitchieG M Fuller
Nov 24, 1995·The Journal of Biological Chemistry·C H HuD W Chung
Dec 9, 2000·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J StenbaekJ Swedenborg
May 23, 2001·Circulation·K G JonesJ T Powell
Nov 5, 2002·The American Journal of Pathology·Vincent FontaineJean-Baptiste Michel
Jun 28, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Fumikazu NomuraKatsuhiko Ihara
Jun 5, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L R SprouseG A Barber
Jun 9, 2004·Circulation·Marcel LeviHarry R Büller
Sep 24, 2004·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·G LatkovskisU Kalnins
Sep 30, 2004·Nature Immunology·Michael C Carroll
Nov 30, 2005·The British Journal of Surgery·N D ForesterS R Carding
Mar 2, 2006·The American Journal of Pathology·Ziad TouatJean-Baptiste Michel
Apr 8, 2006·Stroke; a Journal of Cerebral Circulation·Jerzy KrupinskiLina Badimon
Feb 1, 2007·Journal of Vascular Surgery·Joe DawsonMatt M Thompson
Jul 11, 2009·The British Journal of Surgery·D J ParryD J A Scott
Dec 2, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S ShantikumarD J A Scott

❮ Previous
Next ❯

Citations

Nov 1, 2012·European Heart Journal·Seamus C HarrisonSteve E Humphries
Apr 25, 2012·Mediators of Inflammation·Zong-Zhuang Li, Qiu-Yan Dai
Jul 11, 2014·Annals of Vascular Surgery·Hisato TakagiUNKNOWN All-Literature Investigation of Cardiovascular Evidence Group
Jan 1, 2010·Annals of Vascular Diseases·Koji TsutsumiRyuichi Takahashi
Aug 25, 2012·Journal of the American College of Surgeons·Abhijit GhoshGilbert R Upchurch
Jan 11, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Balachundar SubramaniamJohn G T Augoustides
Aug 19, 2014·The British Journal of Surgery·P W StatherM J Bown
Jan 23, 2014·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P De RangoM Lenti
Aug 17, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·B PulinxW K W H Wodzig
Jul 30, 2014·Thrombosis Research·Katherine I BridgeRobert A S Ariёns
Nov 11, 2014·PloS One·Fraser L MacraeRobert A S Ariëns
Jun 20, 2016·Atherosclerosis·Vivianne B C KokjeJan H N Lindeman
Nov 9, 2016·Seminars in Vascular Surgery·Hisato Takagi, UNKNOWN Takuya Umemoto for the ALICE (All-Literature Investigation of Cardiovascular Evidence) Group
May 25, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Roxana Martinez-PinnaJose L Martin-Ventura
Apr 30, 2016·Journal of the American Heart Association·Gregory T JonesTasnuva D Kabir
Oct 23, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Chetan P HansVidu Garg
Aug 2, 2011·Molecular BioSystems·Tania GamberiPietro Amedeo Modesti
May 29, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shih-Hung TsaiYu-Juei Hsu
Dec 18, 2020·Journal of Cardiovascular Translational Research·Branislav ZagrapanChristine Brostjan
Feb 12, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Wolf EilenbergChristine Brostjan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.