Markers of Intestinal Damage and their Relation to Cytokine Levels in Cardiac Surgery Patients

Shock
Quirine L M HabesMatthijs Kox

Abstract

In patients undergoing cardiac surgery, both extracorporeal circulation (ECC) and intraoperative mesenterial hypoperfusion may account for increased cytokine levels and lead to postoperative gastrointestinal (GI) symptoms. We investigated levels of the intestinal damage markers intestinal fatty acid binding protein (I-FABP in plasma [n = 72] and urine [n = 37]), citrulline (in plasma [n = 35]), and claudin-3 (in urine [n = 37]) in patients undergoing aortic or mitral valve surgery with or without coronary artery bypass grafting. Furthermore, the relationship between these markers and the surgery-induced cytokine response was explored by measuring serial plasma levels of tumor necrosis factor-α, interleukin (IL)-6, IL-8, and IL-10 (n = 35). Finally, the relationship between markers of intestinal damage and GI-symptoms (abdominal pain, ileus, vomiting, diarrhea, time to first defecation) was assessed. Plasma and urinary I-FABP levels, and urinary claudin-3 levels peaked at the end of surgery, while citrulline levels were not influenced by surgery. ECC duration correlated with plasma I-FABP levels (r = 0.31, P = 0.007). Plasma levels of all measured cytokines increased during surgery, with peak levels observed either at the end of...Continue Reading

References

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Citations

Jun 9, 2019·European Journal of Applied Physiology·John O OsborneGeoffrey M Minett
May 24, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·M SikoraL Rudnicka
Sep 28, 2018·Intensive Care Medicine Experimental·David VermetteRichard W Pierce
May 16, 2017·Shock·Max Brenner, Ping Wang
Nov 12, 2020·Microorganisms·Lakshya Sharma, Antonio Riva

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