Markers of oxidative stress and systemic vasoconstriction in pregnant women drinking > or =48 g of alcohol per day.

Alcoholism, Clinical and Experimental Research
Caroline SignoreJames L Mills

Abstract

The precise pathway by which alcohol causes the characteristic features of fetal alcohol spectrum disorders is unknown. Proposed mechanisms for fetal injury from maternal alcohol use include cellular damage from oxidative stress and impaired fetal oxygenation related to maternal systemic vasoconstriction. Our objective was to compare the levels of urinary markers of oxidative stress and systemic vasoconstriction between women consuming large amounts of alcohol during pregnancy and women who did not drink alcohol during pregnancy. Pregnant women consuming > or =48 g alcohol per day (n = 29) on average and pregnant women who abstained from alcohol use (n = 39) were identified using detailed interviews and home visits. Random maternal urine specimens were collected. Urinary levels of the oxidative stress marker, 8-isoprostane F2alpha, and of the vasoactive prostaglandin metabolites, 2,3-dinor-6-keto-prostaglandin F1alpha (a vasodilator) and 11-dehydro-thromboxane B2 (a vasoconstrictor), were measured using mass spectrometric methods. All analyte levels were corrected for urinary creatinine. In crude analyses, there was no significant difference in 8-isoprostane F2alpha between pregnant drinkers and nondrinkers (2.16 vs. 2.08 ng/mg...Continue Reading

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Citations

Jun 26, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Jayanth Ramadoss, Ronald R Magness
Jul 10, 2010·International Journal of Environmental Research and Public Health·Asher Ornoy, Zivanit Ergaz
Jul 8, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Erin M Goldberg, Michel Aliani
Oct 29, 2009·Alcoholism, Clinical and Experimental Research·Theresa W GauthierLou Ann S Brown

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