Markers of oxidative/nitrative damage of plasma proteins correlated with EDSS and BDI scores in patients with secondary progressive multiple sclerosis

Redox Report : Communications in Free Radical Research
Agnieszka MorelJoanna Saluk

Abstract

The objective of the present study was to evaluate oxidative/nitrative stress in the plasma of 50 patients suffering from the secondary progressive course of multiple sclerosis (MS), and to verify its correlation with physical and mental disability as assessed by the Expanded Disability Status Scale (EDSS), and the Beck Depression Inventory (BDI). Oxidative and nitrative damage to proteins was determined by the level of carbonyl groups and 3-nitrotyrosine using ELISA test. Based on the reaction with Ellman's reagent, we estimated the concentration of oxidized thiol groups. Additionally, we measured the level of lipid peroxidation. In plasma drawn from MS patients, we observed a significantly higher level of 3-NT (92%; P < 0.0003), carbonyl groups (29%; P < 0.0001) and thiobarbituric acid reactive substances (73%; P < 0.0001), as well as a lower concentration of thiol groups (33%; P < 0.0001), in comparison to healthy subjects. We noted positive correlations between the level of carbonyl groups or 3-NT and both diagnostic parameters, EDSS and BDI. Negative correlations were observed between concentration of -SH groups and EDSS and BDI. Our results indicate that impaired red-ox balance can significantly promote neurodegeneration ...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·R L LevineE R Stadtman
Jan 1, 1986·Annals of the Rheumatic Diseases·J F KosterA J Swaak
Aug 1, 1966·Analytical Biochemistry·Z A PlacerB C Johnson
Jan 1, 1994·Methods in Enzymology·M L Hu
Jan 1, 1997·Free Radical Biology & Medicine·H BussC C Winterbourn
Apr 18, 1998·The Biochemical Journal·J KhanD M Brennan
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Apr 18, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M KochJ De Keyser
Sep 14, 2007·Platelets·Beata Olas, Barbara Wachowicz
Jun 19, 2008·Annual Review of Neuroscience·Bruce D Trapp, Klaus-Armin Nave
Jul 16, 2009·Journal of Cellular and Molecular Medicine·Shilian LiuYanjiang Qin
Jul 18, 2009·Biochimica Et Biophysica Acta·Peizhong Mao, P Hemachandra Reddy
Nov 26, 2009·Journal of Neuroimmunology·Roopali GandhiHoward L Weiner
Jan 23, 2010·Journal of Proteomics·Jan OttervaldTomas Olsson
Nov 19, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Elżbieta MillerJózef Kędziora
Dec 24, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Athanasios K Petridis, Abderrahman El Maarouf
Feb 24, 2011·Bosnian Journal of Basic Medical Sciences·Almira Hadžović-DžuvoAzra Alajbegović
Mar 2, 2011·Postȩpy higieny i medycyny doświadczalnej·Marzena Gutowicz
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Mar 29, 2011·Neurologic Clinics·Gregory F Wu, Enrique Alvarez
Apr 21, 2011·Multiple Sclerosis : Clinical and Laboratory Research·C E TeunissenC R Jimenez
May 20, 2011·Journal of Alzheimer's Disease : JAD·Larissa Lobo TorresTania Marcourakis
Jun 10, 2011·Brain : a Journal of Neurology·Lukas HaiderHans Lassmann
Aug 23, 2011·FEBS Letters·Hans Lassmann, Jack van Horssen
Oct 25, 2011·Clinical Biochemistry·Elżbieta MillerIreneusz Majsterek
Nov 25, 2011·Journal of the Neurological Sciences·Diana Olga CristalliCarlos Alberto Marra
Mar 14, 2012·Advances in Experimental Medicine and Biology·Elżbieta Miller
Aug 14, 2012·Journal of the Neurological Sciences·Sayonara Rangel OliveiraEdna Maria Vissoci Reiche
Aug 17, 2012·Molecular Medicine Reports·Shoufeng JiangMeiping Ding
Feb 13, 2013·Cardiovascular Psychiatry and Neurology·Alan M Palmer
Mar 12, 2013·Antioxidants & Redox Signaling·Djordje Miljković, Ivan Spasojević
Jul 10, 2013·Current Medicinal Chemistry·E MillerI Majsterek
Nov 1, 2013·Clinical & Developmental Immunology·Norma Y Hernández-PedroJulio Sotelo
Jan 2, 2014·Oxidative Medicine and Cellular Longevity·Aurel Popa-WagnerAna-Maria Buga
Oct 4, 2014·European Neurology·Fred D Lublin
Oct 12, 2014·Clinical Biochemistry·Martin KarlíkPeter Celec
Dec 3, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C-H TsengY-J Chang

❮ Previous
Next ❯

Citations

Oct 8, 2019·The International Journal of Neuroscience·Tobore Onojighofia Tobore
Aug 25, 2018·Journal of Molecular Neuroscience : MN·Annette Liessem-SchmitzAthanassios Fragoulis
Oct 18, 2020·International Journal of Molecular Sciences·Piotr KarabowiczElżbieta Skrzydlewska
Aug 5, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Carmen Peña-BautistaConsuelo Cháfer-Pericás

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.