Markers of sarcopenia quantified by computed tomography predict adverse long-term outcome in patients with resected oesophageal or gastro-oesophageal junction cancer

European Radiology
Dietmar TamandlAhmed Ba-Ssalamah

Abstract

To assess the impact of sarcopenia and alterations in body composition parameters (BCPs) on survival after surgery for oesophageal and gastro-oesophageal junction cancer (OC). 200 consecutive patients who underwent resection for OC between 2006 and 2013 were selected. Preoperative CTs were used to assess markers of sarcopenia and body composition (total muscle area [TMA], fat-free mass index [FFMi], fat mass index [FMi], subcutaneous, visceral and retrorenal fat [RRF], muscle attenuation). Cox regression was used to assess the primary outcome parameter of overall survival (OS) after surgery. 130 patients (65%) had sarcopenia based on preoperative CT examinations. Sarcopenic patients showed impaired survival compared to non-sarcopenic individuals (hazard ratio [HR] 1.87, 95% confidence interval [CI] 1.15-3.03, p = 0.011). Furthermore, low skeletal muscle attenuation (HR 1.91, 95% CI 1.12-3.28, p = 0.019) and increased FMi (HR 3.47, 95% CI 1.27-9.50, p = 0.016) were associated with impaired outcome. In the multivariate analysis, including a composite score (CSS) of those three parameters and clinical variables, only CSS, T-stage and surgical resection margin remained significant predictors of OS. Patients who show signs of sarcop...Continue Reading

References

Apr 29, 1998·American Journal of Epidemiology·R N BaumgartnerR D Lindeman
Nov 10, 2006·The British Journal of Nutrition·Gaëlle CosquéricSébastien Weill-Engerer
Dec 7, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Michael G HousePeter J Allen
Aug 21, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Courtney J BalentineDavid H Berger
Feb 8, 2011·The Lancet Oncology·Kenneth FearonVickie E Baracos
Aug 31, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sherif AwadDileep N Lobo
Mar 27, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa MartinVickie E Baracos
Apr 9, 2013·Acta Radiologica·Lilian HammarstedtMikael Hellström
Oct 15, 2013·Journal of Medical Imaging and Radiation Oncology·David ChangNigel A Spry
Nov 10, 2013·Thoracic Surgery Clinics·Toshitaka Hoppo, Blair A Jobe
Dec 21, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C CastroN Lunet
Aug 8, 2014·Nutrition and Cancer·Josep Manel Llop-TalaveronHumberto Aranda-Danso
Jun 13, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Poorna AnandavadivelanLena Martin

❮ Previous
Next ❯

Citations

Feb 18, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Shlomit Strulov ShacharTomohiro F Nishijima
Aug 20, 2016·Current Oncology Reports·Isabella P CarneiroCarla M Prado
Nov 5, 2016·The Breast : Official Journal of the European Society of Mastology·Hánah N RierMark-David Levin
Jul 28, 2017·Acta Radiologica·Karen De Amorim BernsteinMiriam A Bredella
Sep 9, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Yeonjung HaSeong Gyu Hwang
May 5, 2018·Annual Review of Nutrition·Elizabeth M Cespedes FelicianoBette J Caan
Aug 18, 2018·Journal of Gastroenterology and Hepatology·Kensuke KudouYoshihiko Maehara
Jan 23, 2019·Journal of Cachexia, Sarcopenia and Muscle·Willemieke P M DijksterhuisHanneke W M van Laarhoven
Jun 7, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Lucas StoneDaniel Clayburgh
Sep 16, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F Bozzetti
Mar 21, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Dimitrios PapaconstantinouEmmanouil Pikoulis
Jun 5, 2018·Journal of Geriatric Physical Therapy·Maarten A van EgmondSuzanne S Gisbertz
Mar 21, 2020·Clinical Physiology and Functional Imaging·Taiara Scopel PoltronieriGabriela Villaça Chaves
Feb 26, 2020·Journal of Cachexia, Sarcopenia and Muscle·Eliza R C HagensSuzanne S Gisbertz
Sep 12, 2019·Annals of the Royal College of Surgeons of England·D SchizasK S Mylonas
Sep 13, 2019·Radiation Oncology·Cédric M PanjeUNKNOWN Swiss Group for Clinical Cancer Research (SAKK)
Apr 11, 2018·Annals of Surgical Oncology·Taiichi KawamuraMasanori Terashima
Oct 3, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Takayuki SugaiMasafumi Watanabe
May 31, 2018·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P R BoshierD E Low
Nov 30, 2018·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H-Y DengP Zha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.