PMID: 20623039Jul 14, 2010Paper

Markers of systemic inflammation in periodontal patients: chronic versus aggressive periodontitis. An explorative cross-sectional study.

European Journal of Oral Implantology
Francesco CairoGiovan Paolo Pini-Prato

Abstract

The aim of this study was to evaluate differences in the inflammatory profile of young (<or=40 years) systemically healthy periodontal patients comparing chronic (CP) versus aggressive periodontitis (AP) in terms of cytokines, chemokines and C-reactive protein levels. Systemically healthy subjects affected by severe CP or AP were enrolled in this study. Differential diagnosis was performed according to the criteria suggested by the American Academy of Periodontology. Blood samples for the evaluation of high sensitivity C-reactive protein levels, cytokine levels (IL-1beta, IL-1RA, IL-4, IL-6, IL-10, IL-12, interferon-gamma, interferon-gamma-inducible protein 10, tumour necrosis factor alpha) and chemokine levels (IL-8, vascular endothelial growth factor, monocyte chemoattractant protein 1, macrophage inflammatory protein 1alpha and macrophage inflammatory protein 1beta) were obtained from all patients. A total of 45 systemically healthy patients with severe periodontitis were consecutively selected, 21 with CP (mean age 36.8+/-3.5; mean clinical attachment level [CAL] 4.72+/-0.69) and 24 with AP (mean age 35.9+/-3.8; mean CAL 4.68+/-0.75). No statistically significant difference between the two groups was detected for periodonta...Continue Reading

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