Market penetration of Xpert MTB/RIF in high tuberculosis burden countries: A trend analysis from 2014 - 2016

Gates Open Research
Danielle CazabonMadhukar Pai

Abstract

Background: Xpert® MTB/RIF, a rapid tuberculosis (TB) molecular test, was endorsed by the World Health Organization in 2010. Since then, 34.4 million cartridges have been procured under concessional pricing. Although the roll out of this diagnostic is promising, previous studies showed low market penetration. Methods: To assess 3-year trends of market penetration of Xpert MTB/RIF in the public sector, smear and Xpert MTB/RIF volumes for the year 2016 were evaluated and policies from 2014-2016 within 22 high-burden countries (HBCs) were studied. A structured questionnaire was sent to representatives of 22 HBCs. The questionnaires assessed the total smear and Xpert MTB/RIF volumes, number of modules and days of operation of GeneXpert machines in National TB Programs (NTPs). Data regarding the use of NTP GeneXpert machines for other diseases and GeneXpert procurement by other disease control programs were collected. Market penetration was estimated by the ratio of total sputum smear volume for initial diagnosis divided by the number of Xpert MTB/RIF tests procured in the public sector. Results: The survey response rate was 21/22 (95%). Smear/Xpert ratios decreased in 17/21 countries and increased in four countries, since 2014. The...Continue Reading

References

Nov 2, 2014·The European Respiratory Journal·Zhi Zhen QinJacob Creswell
Jan 27, 2015·The Lancet Global Health·Ren MinghuiBernhard Schwartländer
Feb 10, 2017·PloS One·Kate ClouseUNKNOWN International Epidemiologic Databases to Evaluate AIDS (IeDEA) collaboration
Jul 19, 2017·The Lancet Global Health·Madlen NashShrikala Baliga
Sep 2, 2017·The European Respiratory Journal·Danielle CazabonMadhukar Pai

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Citations

Oct 23, 2018·Current Opinion in HIV and AIDS·Emily MacLeanMadhukar Pai
Aug 8, 2020·Journal of Clinical Microbiology·Emily MacLeanMadhukar Pai
Mar 3, 2020·Wellcome Open Research·James A SeddonUNKNOWN Tuberculous Meningitis International Research Consortium
Jun 8, 2019·The Cochrane Database of Systematic Reviews·David J HorneKaren R Steingart
Feb 6, 2020·Emerging Microbes & Infections·M Jeremiah MatsonVincent J Munster
Nov 21, 2020·Future Microbiology·Sara ConsalviMariangela Biava
Nov 3, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Prakash GaneshSam Phiri
Jan 7, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tobias Broger, Mark P Nicol
Apr 20, 2021·Frontiers in Sociology·Vaibhav Saria
Dec 29, 2020·The Lancet Infectious Diseases·Belinda HengelRebecca Guy
Aug 29, 2019·Pediatrics·Olivier MarcyUNKNOWN ANRS 12229 PAANTHER 01 STUDY GROUP
Jan 26, 2020·The Lancet Global Health·Shahin SayedMarleen Temmermans

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Software Mentioned

GeneXperts
GeneXpert
Smear Xpert analysis
Xpert Ultra GeneXperts

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