Markhacanasin C, cycloartane triterpenoid from the leaves of Markhamia stipulata var. canaense V.S. Dang

Natural Product Research
Trong Nghia NgoTan Phat Nguyen

Abstract

One new cycloartane triterpenoid, named markhacanasin C (1), together with three known triterpenoids, oleanolic acid (2), ursolic acid (3) and 6β,19α-dihydroxyursolic acid (4) were isolated by various chromatographic methods from the most cytotoxic fraction of the ethyl acetate extract of Markhamia stipulata var. canaense V.S. Dang leaves. Among them, 4 was reported for the first time from the genus Markhamia, while 2 and 3 were found for the first time from this species. Their structures were elucidated by IR, UV, HR-ESI-MS and NMR experiments. The cytotoxicity of isolated compounds (3 and 4) against three human cancer cell lines (HeLa, HepG2, and MCF-7) were evaluated. At the concentration of 100 μg/mL, 3 exhibited significant cytotoxic activity (86.36 ± 3.69%).

References

Dec 23, 2015·Journal of Asian Natural Products Research·Tan Phat NguyenDinh Tri Mai
Jul 17, 2016·BMC Complementary and Alternative Medicine·My-Nuong Thi Nguyen, Thuy-Duong Ho-Huynh

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Citations

Jul 23, 2019·Natural Product Research·Nguyen Kim Tuyen PhamTan Phat Nguyen
Mar 20, 2019·Natural Product Research·Dinh Tri MaiTan Phat Nguyen
Oct 28, 2020·Natural Product Research·Bui Linh Chi HuynhTan Phat Nguyen

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Methods Mentioned

BETA
column chromatography

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