Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Shotaro UeharaHiroshi Yamazaki

Abstract

1. Common marmoset (Callithrix jacchus), a New World Monkey, has potential to be a useful animal model in preclinical studies. However, drug metabolizing properties have not been fully understood due to insufficient information on cytochrome P450 (P450), major drug metabolizing enzymes. 2. Marmoset P450 2J2 cDNA was isolated from marmoset livers. The deduced amino acid sequence showed a high-sequence identity (91%) with cynomolgus monkey and human P450 2J2 enzymes. A phylogenetic tree revealed that marmoset P450 2J2 was evolutionarily closer to cynomolgus monkey and human P450 2J2 enzymes, than P450 2J forms in pigs, rabbits, rats or mice. 3. Marmoset P450 2J2 mRNA was abundantly expressed in the small intestine and liver, and to a lesser extent in the brain, lung and kidney. Immunoblot analysis also showed expression of marmoset P450 2J2 protein in the small intestine and liver. 4. Enzyme assays using marmoset P450 2J2 protein heterologously expressed in Escherichia coli indicated that marmoset P450 2J2 effectively catalyzed astemizole O-demethylation and terfenadine t-butyl hydroxylation, similar to human and cynomolgus monkey P450 2J2 enzymes. 5. These results suggest the functional characteristics of P450 2J2 enzymes are si...Continue Reading

References

Apr 15, 1997·Archives of Biochemistry and Biophysics·Q Y ZhangL S Kaminsky
Oct 27, 2001·Circulation Research·I Fleming
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·Takanori HashizumeYoshihiko Funae
Oct 19, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Shigeki MatsumotoYasushi Yamazoe
Aug 12, 2005·American Journal of Physiology. Renal Physiology·John D Imig
Sep 22, 2006·American Journal of Physiology. Cell Physiology·Arthur A Spector, Andrew W Norris
Mar 24, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Jeffrey J IliffNabil J Alkayed
Apr 11, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Fabien DutheilMarie-Anne Loriot
May 30, 2009·Nature·Erika SasakiTatsuji Nomura
Nov 20, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Caroline A LeeRheem A Totah
Mar 13, 2010·Pflügers Archiv : European journal of physiology·William B Campbell, Ingrid Fleming
Dec 16, 2010·Regulatory Toxicology and Pharmacology : RTP·Antonia OrsiGermano Oberto
Mar 9, 2011·Drug Metabolism and Pharmacokinetics·Haruka NishimutaSetsuko Komuro
Mar 18, 2011·ILAR Journal·Suzette D TardifToni E Ziegler
May 10, 2011·Research in Veterinary Science·A MessinaV Longo
Aug 19, 2011·The Journal of Pharmacology and Experimental Therapeutics·Shotaro UeharaYasuhiro Uno
Aug 9, 2012·Seminars in Fetal & Neonatal Medicine·Hideyuki OkanoErika Sasaki
Jan 15, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Joan P GravesDarryl C Zeldin
Sep 12, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Eric A EvangelistaRheem A Totah
Mar 7, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Shotaro UeharaYasuhiro Uno
Jul 21, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Suzette TardifArlan Richardson
Aug 21, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Shotaro UeharaYasuhiro Uno
Mar 25, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Shotaro UeharaHiroshi Yamazaki
Apr 11, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Shotaro UeharaHiroshi Yamazaki
Aug 1, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Shotaro UeharaHiroshi Yamazaki
Oct 28, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Shotaro UeharaHiroshi Yamazaki

❮ Previous
Next ❯

Citations

Jul 21, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Shotaro UeharaHiroshi Yamazaki
Apr 25, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Shotaro UeharaHiroshi Yamazaki
Aug 2, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Kazuyuki NakanishiHiroshi Yamazaki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Shotaro UeharaHiroshi Yamazaki
Drug Metabolism and Disposition : the Biological Fate of Chemicals
Shotaro UeharaHiroshi Yamazaki
Drug Metabolism and Disposition : the Biological Fate of Chemicals
Yasuhiro UnoHiroshi Yamazaki
© 2022 Meta ULC. All rights reserved