Marrow adipogenesis and bone loss that parallels estrogen deficiency is slowed by low-intensity mechanical signals

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Divya KrishnamoorthyClinton T Rubin

Abstract

Ovariectomized mice were used to assess the ability of low-intensity vibrations to protect bone microarchitecture and marrow composition. Results indicate that low-intensity vibrations (LIV), introduced 2 weeks postsurgery, slows marrow adipogenesis in OVX mice but does not restore the bone within the period studied. However, immediate application of LIV partially protects quality. The aim of this study was to evaluate consequences of estrogen depletion on bone marrow (BM) phenotype and bone microarchitecture, and effects of mechanical signals delivered as LIV on modulating these changes. LIV (0.3 g, 90 Hz) was applied to C57BL/6 mice immediately following ovariectomy or 2 weeks postestrogen withdrawal for 2 (ST-LIV) or 6 weeks (LT-LIV), respectively. Sham-operated age-matched controls (ST-AC, LT-AC) and ovariectomized controls (ST-OVX, LT-OVX) received sham LIV treatment. Bone microstructure was evaluated through μCT and BM adipogenesis through histomorphometry, serum markers, and genes expression analysis. LT-OVX increased BM adipogenesis relative to LT-AC (+136 %, p ≤ 0.05), while LT-LIV introduced for 6w suppressed this adipose encroachment (-55 %, p ≤ 0.05). In parallel with the fatty marrow, LT-OVX showed a marked loss of...Continue Reading

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Citations

Jul 6, 2016·Frontiers in Endocrinology·Mark W HamrickDanielle M Frechette
Aug 18, 2016·Biomechanics and Modeling in Mechanobiology·Naama ShohamAmit Gefen
Feb 25, 2018·Current Osteoporosis Reports·Vihitaben S PatelClinton T Rubin
Feb 6, 2018·Current Molecular Biology Reports·Carolyne FalankMichaela R Reagan
Sep 12, 2017·Annals of the New York Academy of Sciences·Danielle M FrechetteClinton T Rubin
Mar 29, 2019·JBMR Plus·Majdi MasarwiMichaela R Reagan
Nov 3, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tee PamonClinton T Rubin
May 25, 2018·Journal of Medicinal Food·Suresh AmbatiSrujana Rayalam
Mar 1, 2019·Nature Reviews. Endocrinology·Gabriel M PagnottiClinton T Rubin
Jun 2, 2020·Frontiers in Endocrinology·Andrea Benova, Michaela Tencerova
Oct 18, 2020·Current Osteoporosis Reports·Sarah E Little-LetsingerMaya Styner

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