PMID: 8016Jun 1, 1976

Marrow transplantation in treatment of children with aplastic anaemia or acute leukaemia

Archives of Disease in Childhood
F L JohnsonRainer Storb

Abstract

Seventy-six patients, aged 2 to 17 years, were treated with bone marrow transplantation for severe aplastic anaemia or acute leukaemia refractory to conventional therapy. 16 of the 22 patients (73%) who received marrow transplantations for aplastic anaemia are surviving, 12 of these for over one year. In acute leukaemia, using preparation with cyclophosphamide and total body irradiation, 8 of 33 patients (24%) receiving allogeneic and 5 of 8 (63%) receiving syngeneic transplantations are continuing in remission from 3 months to beyond 2 years. The longest continuing remission off therapy is now over 4 1/2 years after preparation with total body irradiation. The major causes of failure remain graft-versus-host disease, infection, graft rejection (aplastic anaemia), and leukaemic relapse.

References

Apr 17, 1975·The New England Journal of Medicine·E D ThomasC D Buckner
Apr 24, 1975·The New England Journal of Medicine·E D ThomasC D Buckner
Sep 1, 1975·Proceedings of the Royal Society of Medicine·J G Humble, A J Barrett
Apr 22, 1972·Lancet·S Davis, A D Rubin
Jun 17, 1972·Lancet·E D ThomasRainer Storb
Jan 1, 1974·Annual Review of Medicine·P NeimanK G Lerner
Jun 20, 1974·The New England Journal of Medicine·A FeferRainer Storb
Apr 26, 1971·JAMA : the Journal of the American Medical Association·D Pinkel
Jan 1, 1975·Journal of Pediatric Surgery·Melvin D Levine

Related Concepts

Hypoplastic Anemia
Bone Marrow Cells
Graft Rejection
Graft Vs Host Reaction
Lymphoid Leukemia
Remission, Spontaneous
Transplantation, Homologous
Acute Myeloid Leukemia, M1
Bone Marrow Cell Transplantation

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