Marsupialization of percutaneous implants in presence of deep connective tissue

Journal of Biomedical Materials Research
T G HeaneyD F Williams

Abstract

The primary substratum for epithelial migration during marsupialization of percutaneous implants is adjacent connective tissue. The purpose of this investigation was to test the hypothesis that if the latter is composed of deep connective tissue or other deep tissue, it will inhibit this process. One-hundred-forty-two smooth-surfaced polyethylene implants of a simple geometric design were implanted in dorsal skin of 6-8-week-old male C57/BL/6 mice such that the stems passed through and deep to the panniculus carnosus (PC), which is a deep tissue. Animals were sacrificed in groups between 1 and 11 weeks, and the implants and surrounding tissue were harvested, embedded in historesin, and 3-microns thick step serial sections prepared. No implants were lost by extrusion and 133 were suitable for examination. Epithelial investment of the devices proceeded deep to PC around only five of the implants over the time course. In the remainder, the mean distance of the advancing epithelial edge from the upper border of the PC was 0.25 mm by 1 week and this did not change significantly thereafter (p = 0.647). Significant extrusion of all devices occurred (p = 0.0001). It was concluded that these results are consistent with the hypothesis th...Continue Reading

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Citations

Aug 19, 2008·Biomedical Materials·P Fleckman, J E Olerud
Jul 23, 2008·Journal of Biomaterials Science. Polymer Edition·John E Olerud
Aug 10, 2010·Journal of Biomedical Materials Research. Part a·Y FukanoP Fleckman
Jun 15, 2007·Journal of Biomedical Materials Research. Part a·S N IsenhathJ E Olerud
Jun 29, 2005·Journal of Biomedical Materials Research. Part a·Negar G KnowlesJohn E Olerud
Jun 7, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Eleonore C L BolleTim R Dargaville
Apr 18, 2008·The Laryngoscope·Roya AzadarmakiGlenn Isaacson
May 8, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Divya R L PawarKent N Bachus
Jul 22, 2019·Colloids and Surfaces. B, Biointerfaces·Alexis Trent, Mark E Van Dyke

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