MARveling at parasite invasion.

Trends in Parasitology
Kristin M Hager, Vern B Carruthers

Abstract

Micronemal proteins (MICs) are key mediators of cytoadherence and invasion for Toxoplasma gondii. Emerging evidence indicates that carbohydrate binding facilitates Toxoplasma entry into host cells. The recently solved Toxoplasma MIC1s (TgMIC1s) structure reveals the presence of novel specialized domains that can discriminate between glycan residues. Comparison with Plasmodium erythrocyte-binding antigen 175 reveals that terminal sialic acid residues might represent a shared but tailored invasion pathway among apicomplexan parasites.

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Citations

May 16, 2009·Nature Reviews. Microbiology·Gerardo R Vasta
Apr 15, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Emmanuelle Pales EspinosaBassem Allam
Nov 28, 2015·Journal of Proteomics·Emmanuelle Pales EspinosaBassem Allam
Oct 28, 2016·The Journal of Eukaryotic Microbiology·ZhenChao ZhangXiangRui Li

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