MAS NMR of HIV-1 protein assemblies

Journal of Magnetic Resonance
Christopher L SuiterTatyana Polenova

Abstract

The negative global impact of the AIDS pandemic is well known. In this perspective article, the utility of magic angle spinning (MAS) NMR spectroscopy to answer pressing questions related to the structure and dynamics of HIV-1 protein assemblies is examined. In recent years, MAS NMR has undergone major technological developments enabling studies of large viral assemblies. We discuss some of these evolving methods and technologies and provide a perspective on the current state of MAS NMR as applied to the investigations into structure and dynamics of HIV-1 assemblies of CA capsid protein and of Gag maturation intermediates.

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Citations

Dec 29, 2015·The Journal of Physical Chemistry. B·Rupal GuptaTatyana E Polenova
Feb 17, 2018·Biomolecular NMR Assignments·Lauriane LecoqAnja Böckmann
Sep 30, 2020·Viruses·Lauriane LecoqAnja Böckmann
Sep 30, 2021·Annual Review of Virology·Gal Porat-DahlerbruchTatyana Polenova

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