Nov 7, 2019

Mash Screen: high-throughput sequence containment estimation for genome discovery

Genome Biology
Brian D. OndovAdam M. Phillippy


The MinHash algorithm has proven effective for rapidly estimating the resemblance of two genomes or metagenomes. However, this method cannot reliably estimate the containment of a genome within a metagenome. Here, we describe an online algorithm capable of measuring the containment of genomes and proteomes within either assembled or unassembled sequencing read sets. We describe several use cases, including contamination screening and retrospective analysis of metagenomes for novel genome discovery. Using this tool, we provide containment estimates for every NCBI RefSeq genome within every SRA metagenome and demonstrate the identification of a novel polyomavirus species from a public metagenome.

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Mentioned in this Paper

Steroid receptor RNA activator
Ncbi Taxonomy
Screening Generic
Retrospective Studies
Drug Discovery

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