PMID: 9543267May 16, 1998Paper

Mask intermittent positive pressure ventilation in chronic hypercapnic respiratory failure due to chronic obstructive pulmonary disease

The European Respiratory Journal
P SivasothyJ M Shneerson

Abstract

Noninvasive ventilation in chronic obstructive pulmonary disease (COPD) has been shown to improve arterial blood gases but its long-term role has not been established. We retrospectively studied 26 consecutive patients with hypercapnic ventilatory failure due to COPD in whom oxygen therapy caused worsening hypercapnia (defined as a rise in the daytime arterial carbon dioxide tension (Pa,CO2) to >8.0 kPa or nocturnal transcutaneous carbon dioxide tension (Ptc,CO2) to >9 kPa). All were treated with mask ventilation (15 with nasal and 11 face masks) at night and during daytime naps. Additional oxygen therapy was required in 15 patients. The mean annualized death rate was 10.8% with a 1 and 3 yr survival of 92 and 68%, respectively. After 1 yr the median daytime Pa,CO2 had fallen by 1.35 kPa and the arterial oxygen tension (Pa,O2) had risen by 2.4 kPa. In subjects not using additional oxygen the median overnight Sa,O2 rose by 12% and the Ptc,CO2 fell by 2.8 kPa after 1 yr. The haematocrit was significantly less than pretreatment at 6 months and 1 yr. Quality of life in the domain of role limitation by physical health (measured using the SF-36 questionnaire) improved significantly at 6 months. Survival in this selected group with cl...Continue Reading

Citations

Nov 30, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Oreste MarroneGiuseppe Insalaco
Dec 1, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Salvador Díaz-LobatoEsteban Pérez Rodríguez
Mar 12, 2009·International Journal of Medical Sciences·Wolfram WindischMichael Dreher
May 2, 2007·Sleep Medicine·Dominique Robert, Laurent Argaud
Feb 24, 2001·Clinics in Chest Medicine·N S Hill
Apr 26, 2014·International Journal of Nursing Practice·Heidi MarkussenGerd K Natvig
Feb 19, 2008·Respiratory Medicine·Vasiliki TsolakiKonstantinos Kostikas
Mar 27, 2007·Respiratory Medicine·Nicolino Ambrosino, Anita Simonds
Jun 14, 2005·Respiratory Medicine·Stephan BudweiserMichael Pfeifer
May 14, 2004·Respiratory Medicine·Nicolino Ambrosino, Enrico Clini
Nov 9, 2007·Respiration; International Review of Thoracic Diseases·Brigitte FaurouxAnnick Clément
Feb 24, 2001·Clinics in Chest Medicine·E Marchand, M Decramer
Feb 28, 2008·Current Opinion in Pulmonary Medicine·Stephan BudweiserMichael Pfeifer
Jun 16, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Nicholas S OscroftIan E Smith
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·S Mehta, N S Hill
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Oct 13, 2021·BMC Pulmonary Medicine·Marwan F AlawiehSalah M Zeineldine

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