Masked clozapine-induced cardiomyopathy

Journal of the American Board of Family Medicine : JABFM
Charles A Pastor, Monica Mehta

Abstract

A 33-year-old Latin-American woman with a history of psychosis and mood disorder, but no cardiac history or risk factors, presented with heart failure after 6 weeks of clozapine and olanzapine therapy. Her presentation was ambiguous and further complicated by a highly suggestible nature, which delayed the proper diagnosis and treatment. After discontinuing the antipsychotic agents and completing an otherwise negative comprehensive work-up, her heart function significantly improved (left ventricular ejection fraction increased from 38% to 53%). A literature search showed that cardiomyopathy secondary to antipsychotics has been reported but remains poorly understood. This is the second documented case report of clozapine-induced cardiomyopathy in a Latin-American woman.

Citations

Jun 28, 2011·BMC Bioinformatics·Qian ZhuDavid J Wild
Aug 19, 2014·International Journal of Cardiology·Mohammed AlawamiChristopher Kenedi
Jul 17, 2008·European Journal of Pharmacology·Ju-Feng WangJames P Morgan
Sep 29, 2015·Case Reports in Cardiology·Ronny CohenRobert McCue
May 26, 2016·Current Psychiatry Reports·Martina CurtoRoss J Baldessarini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Journal of Clinical Pharmacy and Therapeutics
P M WehmeierH Remschmidt
Journal of Clinical Psychopharmacology
David B MerrillDonald C Goff
Journal of Clinical Psychopharmacology
S HäggT G Soderström
© 2021 Meta ULC. All rights reserved