Maskless fabrication of cell-laden microfluidic chips with localized surface functionalization for the co-culture of cancer cells

Biofabrication
Q HamidW Sun

Abstract

The utilization of the microfabrication technique to fabricate advanced computing chips has exponentially increased in the last few decades. Needless to say, this fabrication technique offers some unique advantages to develop micro-systems. Though many conventional microfabrication techniques today uses very harsh chemicals, the authors believe that the manipulation of system components and fabrication methods may aid in the utilization of the microfabrication techniques used in fabricating computer chips to develop advanced biological microfluidic systems. Presented in this paper is a fabrication approach in which popular fabrication methods and techniques are coupled together to develop an integrated system that aids in the fabrication of cell-laden microfluidic systems. This system aims to reduce the uses of harsh chemicals and decreases the lengthy fabrication time. Additionally, this integrated system will enable the printing of cells as the microfluidic chip is being fabricated. To demonstrate the unique capabilities of the integrated system, an advanced microfluidic chip is being fabricated and investigated. The advanced chip will feature the investigation of cancer cells in a co-cultured microfluidic environment. The in...Continue Reading

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Citations

Jul 18, 2016·Trends in Biotechnology·Stephanie KnowltonSavas Tasoglu
Dec 24, 2015·Biofabrication·Jessica SnyderWei Sun
Oct 20, 2017·Journal of Biomedical Science·Yufeng Zhou
Jun 21, 2016·Biofabrication·Stephanie KnowltonSavas Tasoglu
Aug 25, 2017·Biofabrication·Louis Jun Ye OngYi-Chin Toh
Aug 1, 2020·Micromachines·Joseph R Puryear IiiYongTae Kim
Oct 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shengli MiWei Sun
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May 3, 2019·ACS Applied Materials & Interfaces·David A KidwellShawn P Mulvaney

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