Maskless imaging of dense samples using pixel super-resolution based multi-height lensfree on-chip microscopy.

Optics Express
Alon Greenbaum, Aydogan Ozcan

Abstract

Lensfree in-line holographic microscopy offers sub-micron resolution over a large field-of-view (e.g., ~24 mm2) with a cost-effective and compact design suitable for field use. However, it is limited to relatively low-density samples. To mitigate this limitation, we demonstrate an on-chip imaging approach based on pixel super-resolution and phase recovery, which iterates among multiple lensfree intensity measurements, each having a slightly different sample-to-sensor distance. By digitally aligning and registering these lensfree intensity measurements, phase and amplitude images of dense and connected specimens can be iteratively reconstructed over a large field-of-view of ~24 mm2 without the use of any spatial masks. We demonstrate the success of this multi-height in-line holographic approach by imaging dense Papanicolaou smears (i.e., Pap smears) and blood samples.

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Citations

Jun 27, 2014·Lab on a Chip·Zoltán Göröcs, Aydogan Ozcan
Oct 3, 2013·PloS One·Alon GreenbaumAydogan Ozcan
Jul 1, 2014·ACS Nano·Euan McLeodAydogan Ozcan
Mar 12, 2016·Scientific Reports·Wei LuoAydogan Ozcan
Apr 6, 2013·IEEE Reviews in Biomedical Engineering·Zoltán Göröcs, Aydogan Ozcan
May 20, 2015·Virchows Archiv : an International Journal of Pathology·Yibo ZhangAydogan Ozcan
Dec 19, 2014·Science Translational Medicine·Alon GreenbaumAydogan Ozcan
Jun 30, 2016·Scientific Reports·Yichen WuAydogan Ozcan
Jul 16, 2016·Annual Review of Biomedical Engineering·Aydogan Ozcan, Euan McLeod
Mar 7, 2019·Light, Science & Applications·Yair RivensonAydogan Ozcan
Oct 10, 2012·Lab on a Chip·Hongying ZhuAydogan Ozcan
Jul 17, 2019·Journal of Biophotonics·Tairan LiuAydogan Ozcan
Oct 19, 2017·Biology of Reproduction·Mustafa Ugur Daloglu, Aydogan Ozcan
May 24, 2016·Reports on Progress in Physics·Euan McLeod, Aydogan Ozcan
Oct 28, 2019·Light, Science & Applications·Yibo ZhangAydogan Ozcan
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Feb 8, 2019·Light, Science & Applications·Yair RivensonAydogan Ozcan
Jun 6, 2019·Optics Express·Jarom Jackson, Dallin Durfee
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Dec 3, 2016·Scientific Reports·Yair RivensonAydogan Ozcan
Sep 3, 2017·Methods : a Companion to Methods in Enzymology·Yichen Wu, Aydogan Ozcan
May 15, 2021·Optics Express·Changchun LuJingang Zhong

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Methods Mentioned

BETA
chip
super-resolution holographic microscopy

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