Maslinic acid protects against obesity-induced nonalcoholic fatty liver disease in mice through regulation of the Sirt1/AMPK signaling pathway

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Chian-Jiun LiouWen-Chung Huang

Abstract

Maslinic acid is a pentacyclic triterpenoid that is distributed in the peel of olives. Previous studies found that maslinic acid inhibited inflammatory response and antioxidant effects. We investigated whether maslinic acid ameliorates nonalcoholic fatty liver disease in mice with high-fat-diet (HFD)-induced obesity and evaluated the regulation of lipogenesis in hepatocytes. Male C57BL/6 mice fed a normal diet or HFD (60% fat, w/w) were tested for 16 wk. After the fourth week, mice were injected intraperitoneally with maslinic acid for 12 wk. In another experiment, HepG2 cells were treated with oleic acid to induce lipid accumulation or maslinic acid to evaluate lipogenesis. Maslinic acid significantly reduced body weight compared with HFD-fed mice. Maslinic acid reduced liver weight and liver lipid accumulation and improved hepatocyte steatosis. Furthermore, serum glucose, leptin, and free fatty acid concentrations significantly reduced, but the serum adiponectin concentration was higher, in the maslinic acid group than in the HFD group. In liver tissue, maslinic acid suppressed transcription factors involved in lipogenesis and increased adipose triglyceride lipase. In vitro, maslinic acid decreased lipogenesis by activating A...Continue Reading

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Citations

Nov 7, 2019·Archives of Physiology and Biochemistry·Akinjide Moses AkinnugaAndile Khathi
Dec 14, 2019·World Journal of Gastroenterology : WJG·Xue-Yang ChenChao-Hui Yu
Jan 19, 2021·Journal of Ethnopharmacology·Wen ZhangBangjiang Fang
Feb 7, 2021·The Journal of Nutritional Biochemistry·Shu-Ju WuChian-Jiun Liou
May 17, 2021·European Journal of Medicinal Chemistry·Carlos Villarroel-VicenteNuria Cabedo
Jul 2, 2021·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Ning WangNa Xiao
Oct 17, 2020·Drug Design, Development and Therapy·Fan YangShaohui Xu
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Martina S SavovaMilen I Georgiev
Aug 31, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xu-Ping QianYong-Qing Wang
Nov 2, 2021·Journal of Nutritional Science and Vitaminology·Takanaga ShiraiTohru Takemasa

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