Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis

Proceedings of the National Academy of Sciences of the United States of America
Michael L CherShijie Sheng

Abstract

Emerging evidence indicates that tumor-associated proteolytic remodeling of bone matrix may underlie the capacity of tumor cells to colonize and survive in the bone microenvironment. Of particular importance, urokinase-type plasminogen activator (uPA) has been shown to correlate with human prostate cancer (PC) metastasis. The importance of this protease may be related to its ability to initiate a proteolytic cascade, leading to the activation of multiple proteases and growth factors. Previously, we showed that maspin, a serine protease inhibitor, specifically inhibits PC-associated uPA and PC cell invasion and motility in vitro. In this article, we showed that maspin-expressing transfectant cells derived from PC cell line DU145 were inhibited in in vitro extracellular matrix and collagen degradation assays. To test the effect of tumor-associated maspin on PC-induced bone matrix remodeling and tumor growth, we injected the maspin-transfected DU145 cells into human fetal bone fragments, which were previously implanted in immunodeficient mice. These studies showed that maspin expression decreased tumor growth, reduced osteolysis, and decreased angiogenesis. Furthermore, the maspin-expressing tumors contained significant fibrosis a...Continue Reading

References

Jan 1, 1992·Advances in Experimental Medicine and Biology·J ShimazakiS Isaka
Jan 1, 1987·Cardiology·L F Chasseaud
May 1, 1994·Cancer·V RatanatharathornJ Grimm
Dec 31, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·T NonakaO Matsuo
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C W CrowleyA D Levinson
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·S ShengR Sager
Mar 28, 1997·The Journal of Biological Chemistry·T InuiT Yamamura
Feb 12, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P A PembertonM C Kiefer
Sep 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·V EvertsW Beertsen
Sep 19, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R D Rubens
Feb 2, 2000·Nature Medicine·M ZhangN Bouck
Aug 11, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·V Gurewich
Jul 14, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·M S Pepper
Jan 5, 2002·Journal of the National Cancer Institute·Jeffrey A NemethMichael L Cher
Jan 15, 2002·The Journal of Biological Chemistry·Oliver E Blacque, D Margaret Worrall
Jun 18, 2002·Clinical & Experimental Metastasis·Mario Del RossoVincenzo Chiarugi
Jul 13, 2002·Cancer·Kelly M McMastersMichael J Edwards
Aug 3, 2002·Nature Reviews. Cancer·Gregory R Mundy
Oct 3, 2002·Journal of the National Cancer Institute·Fred SaadUNKNOWN Zoledronic Acid Prostate Cancer Study Group
Oct 18, 2002·The Journal of Biological Chemistry·Rosemary BassVincent Ellis
Nov 14, 2002·The Prostate·Christopher R PiersonShijie Sheng

❮ Previous
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Citations

Dec 21, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marcus BrandJean-Marie Gasc
Jul 13, 2006·World Journal of Urology·Wolf-D BeeckenRoman Blaheta
Jul 4, 2012·Cancer Metastasis Reviews·Thomas M BodenstineMary J C Hendrix
Apr 29, 2010·Current Osteoporosis Reports·Kalyan C Nannuru, Rakesh K Singh
May 10, 2005·Experimental and Molecular Pathology·Laura N GlasscockFrank C Church
Jul 12, 2005·Oncogene·Anastasios TahmatzopoulosNatasha Kyprianou
Aug 18, 2010·The Journal of Biological Chemistry·Li Qin, Ming Zhang
May 1, 2010·Nutrition and Cancer·Shannon Reagan-ShawNihal Ahmad
Mar 23, 2007·Acta Pharmacologica Sinica·Mei-lan HeJian-ye Zhang
Jun 17, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Michèle J Hoffmann, Wolfgang A Schulz
Jun 24, 2006·American Journal of Respiratory Cell and Molecular Biology·Eric K ChuJeffrey M Drazen
Sep 29, 2011·Diagnostic Pathology·Shaimaa E GhazyHoury M Baghdadi
Nov 13, 2012·Critical Reviews in Eukaryotic Gene Expression·Alexander KaplunShijie Sheng
Aug 30, 2008·International Journal of Biological Sciences·Yan-gao Man, William A Gardner
Apr 4, 2009·International Journal of Biological Sciences·Aijun LiuYan-Gao Man
Jan 22, 2014·Nature Communications·Sonia S Y TeohPhillip I Bird
Aug 8, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chun-Te WuHui-Hsiung Liu
Oct 22, 2013·Pharmacology & Therapeutics·Mark Esposito, Yibin Kang
Apr 21, 2010·Expert Opinion on Investigational Drugs·Ralf HildenbrandPhilipp Stroebel
Sep 4, 2015·International Journal of Molecular Medicine·Jun ZhouFeng Guo
Aug 12, 2009·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Soung Min KimJong Ho Lee
Feb 6, 2009·Gynecologic Oncology·Dagmara Klasa-MazurkiewiczJanusz Emerich
May 13, 2008·Cancer Treatment Reviews·Xuenong ZouCody Bünger
Mar 28, 2008·Urologic Oncology·Devon C HallSusan S Padalecki
Dec 18, 2007·Biochimica Et Biophysica Acta·Thomas J Wilson, Rakesh K Singh
Aug 10, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·H Kumamoto, K Ooya

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