Abstract
The potential role of decreased respiratory muscle mass, if any, in mediating the susceptibility to exacerbation in COPD patients has not been determined. We hypothesized that a decrease in respiratory muscle mass is associated with increased risk of multiple hospital admissions due to acute exacerbations of the disease. Eligible cases and controls (n=20) were identified from records of our department's pulmonary clinic. Ten subjects diagnosed with COPD (males, 66+/-7yr, Body Mass Index (BMI)=26+/-4kg/m(2)) were identified as fragile patients. Fragility was defined as four or more admissions in the previous year due to severe exacerbations of the disease. Fragile patients were matched with 10 non-fragile controls, defined as COPD patients who had required only one admission due to exacerbation of the disease. Criteria for 1:1 matching included ethnicity, gender, age, BMI, degree of airflow obstruction (i.e., FEV(1)), comorbidity and chronic treatment. Multiple computed tomography (CT) scan slices were obtained to assess area and attenuation coefficients of multiple upper limb, thorax, abdomen and lower limb muscles. CSA of intercostal and abdominal muscles was significantly decreased in fragile COPD patients (right side interco...Continue Reading
References
Oct 1, 1991·Thorax·A M ScholsE F Wouters
May 1, 1989·Radiology·C I CaskeyA D Rahmouni
Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonC R MacKenzie
May 1, 1995·Chest·Y NishimuraM Yokoyama
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·K Gray-DonaldJ G Martin
Jan 1, 1996·Thorax·A A OkubadejoJ A Wedzicha
May 3, 1997·Lancet·C J Murray, A D Lopez
Dec 5, 1997·The European Respiratory Journal·M A VermeerenE F Wouters
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·A M ScholsE F Wouters
Aug 12, 1998·American Journal of Respiratory and Critical Care Medicine·S BernardF Maltais
Mar 5, 1999·The European Respiratory Journal·M Orozco-LeviJ M Broquetas
Jun 11, 1999·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·E J MetterB Hurley
Aug 31, 1999·The Proceedings of the Nutrition Society·J Congleton
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·C LandboT P Almdal
May 8, 2000·Journal of the American Geriatrics Society·M VisserL M Bouter
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·R A PauwelsUNKNOWN GOLD Scientific Committee
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·M Orozco-LeviJ Gea
Sep 17, 2002·American Journal of Respiratory and Critical Care Medicine·Karine MarquisFrançois Maltais
Oct 3, 2002·The European Respiratory Journal·E PrescottP Lange
Nov 28, 2002·Thorax·E F M Wouters
Jan 30, 2003·Thorax·J Garcia-AymerichUNKNOWN Estudi del Factors de Risc d'Agudització de la MPOC investigators
Mar 1, 2003·The European Respiratory Journal·A G N AgustíX Busquets
Jun 29, 2004·The European Respiratory Journal·B R CelliUNKNOWN ATS/ERS Task Force
Aug 6, 2004·The European Respiratory Journal·C CoronellJ Gea
Aug 2, 2005·Thorax·J J Soler-CataluñaR Ochando
Sep 2, 2005·The European Respiratory Journal·C M ParkerD E O'Donnell
Oct 21, 2005·Chest·Juan José Soler-CataluñaMiriam Navarro
Aug 25, 2006·Thorax·M J ConnollyUNKNOWN British Thoracic Society and the Royal College of Physicians Clinical Effectiveness Evaluation Unit (CEEu)
Sep 15, 2006·Ultrastructural Pathology·Mauricio Orozco-LeviJoaquim Gea
Citations
Feb 25, 2014·Annals of the American Thoracic Society·Merry-Lynn N McDonaldGeorge R Washko
May 9, 2014·Academic Radiology·Mi Jung ParkHwa Seon Shin
Dec 17, 2015·Clinical Physiology and Functional Imaging·Young Saing KimHyung Sik Kim
Dec 25, 2015·Annals of the American Thoracic Society·Kazuya TanimuraShigeo Muro
Jan 6, 2017·The Clinical Respiratory Journal·Sunmi JuHo Cheol Kim
Mar 20, 2018·American Journal of Respiratory and Critical Care Medicine·Ariel Jaitovich, Esther Barreiro
Dec 16, 2017·The European Respiratory Journal·Merry-Lynn N McDonaldGeorge R Washko
Jan 31, 2012·Expert Review of Respiratory Medicine·Joaquim GeaEsther Barreiro
Jul 6, 2016·Current Opinion in Supportive and Palliative Care·Deborah Dudgeon, Vickie E Baracos
Aug 9, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Yuki YoshimatsuYoshitaka Oku
Dec 13, 2019·Journal of Intensive Care·Nobuto NakanishiMasaji Nishimura
Oct 17, 2018·Scientific Reports·Peter WallbridgeDaniel Steinfort
Apr 25, 2020·International Journal of Molecular Sciences·Kun Woo KimMee-Sup Yoon
Jul 16, 2019·ERJ Open Research·Isaac AlmendrosChristopher D Turnbull
Nov 3, 2020·Expert Review of Respiratory Medicine·Harry R GoskerSami O Simons
Jan 17, 2021·Respiratory Research·Toru ShirahataHidetoshi Nakamura
Dec 17, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Peter WallbridgeDaniel Steinfort
Mar 5, 2019·Respiratory Medicine·Jamie S ShethKevin R Flaherty
Sep 28, 2017·Respiratory Medicine·Dmitry RozenbergSunita Mathur