Mass screening for liver cancer: results from a demonstration screening project in Zhongshan City, China

Scientific Reports
Ming-Fang JiWeimin Ye

Abstract

Current Chinese national guidelines recommend routine screening for liver cancer in patients positive for HBsAg, irrespective of fibrosis status, age, or family history of liver cancer. We aim to evaluate whether the recommended screening strategy could reduce liver-cancer-specific mortality. We conducted a liver cancer mass screening trial in Xiaolan Town, Zhongshan City, China, among residents aged 35-64 years in 2012. All volunteers were offered serological testing for hepatitis B virus surface antigen (HBsAg). We proposed biannual screening using serum alpha-fetoprotein (AFP) and ultrasonography examination for subjects positive for HBsAg. Among 17,966 participants (26.2% of 68,510 eligible residents) who were free of liver cancer at baseline in 2012, we identified 57 incident cases of liver cancer within the first 4 years of follow-up (i.e., 43 among 2,848 HBsAg-positive participants and 14 among 15,118 HBsAg-negative participants), compared with 104 cases identified in non-participants (N = 50,544). A total of 207 participants had the recommended number of ultrasonography examinations (every 6 months) during the screening period. Compared with cases identified from non-participants, the cases arising among participants we...Continue Reading

References

Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Bruix
Jan 24, 2004·Journal of Medical Screening·J-G ChenY-R Zhu
Mar 26, 2004·Journal of Cancer Research and Clinical Oncology·Bo-Heng ZhangZhao-You Tang
Apr 7, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hwai-I YangChien-Jen Chen
Feb 15, 2011·Therapeutic Advances in Gastroenterology·Hashem B El-Serag, Jessica A Davila
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Rajeswari AghoramJames A Dickinson
Oct 18, 2012·Journal of the National Cancer Institute·Chi-Pang WenXifeng Wu
Mar 20, 2013·Current Opinion in Gastroenterology·Kunjali T PadhyaAmit G Singal
Sep 5, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yen-Po YehUNKNOWN Changhua Community-Based Abdominal Ultrasonography Screening Group
Jan 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Jin-Hu FanPaolo Boffetta
Jun 18, 2014·Annals of Internal Medicine·Devan KansagaraJanice H Jou
Apr 17, 2015·Human Vaccines & Immunotherapeutics·Xueyan Liao, Zhenglun Liang
Jul 7, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Catherine de MartelSilvia Franceschi
Oct 13, 2015·World Journal of Gastroenterology : WJG·Nobuhiro TsuchiyaTetsuya Nakatsura
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Jan 29, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julie K HeimbachJorge A Marrero

❮ Previous
Next ❯

Citations

May 3, 2020·Cancer Communications·Maomao CaoWanqing Chen
May 17, 2019·Nature Reviews. Urology·Sarah S DingesLeo L Cheng
Oct 1, 2020·International Journal of Cancer. Journal International Du Cancer·Ju-Fang ShiWanqing Chen
Feb 2, 2021·International Journal of Cancer. Journal International Du Cancer·Chengxiao YuUNKNOWN China Kadoorie Biobank Collaborative Group
Mar 9, 2021·Cancer Letters·Maomao CaoWanqing Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
surgical resection

Clinical Trials Mentioned

NCT02501980

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.