Mass spectral fragmentation reactions of a therapeutic 4-azasteroid and related compounds

Journal of the American Society for Mass Spectrometry
D J BurinskyS L Sides

Abstract

Mass spectra were acquired for a therapeutic 4-azasteroid (dutasteride), and some related compounds, using various ionization conditions (EI, CI, APCI and ESI) in both positive and negative ion modes. The ionization and fragmentation behavior of the compound dutasteride, its precursors and several analogs is reported. Positive atmospheric pressure chemical ionization (APCI+) and positive electrospray ionization (ESI+) produced distinctive collision-induced dissociation (CID) spectra for the respective [MH]+ ions of dutasteride. The spectral differences are attributed to ion populations having either different structures or different internal energy distributions (as a consequence of the method of ionization). Irrespective of their origin, the protonated molecules undergo interesting fragmentation reactions when collisionally activated. The identity of the major fragmentation products was confirmed by accurate mass measurement. The negative APCI mass spectrum of dutasteride displays extensive dehydrohalogenation, apparently due to the thermal component of the APCI process. Some of the resulting radical anions display remarkable stability toward collisional decomposition. Details of the fragmentation behavior for the negative ion...Continue Reading

References

Oct 1, 1990·Biomedical & Environmental Mass Spectrometry·J A CampbellM J Connolly
Jan 1, 1987·Journal of Steroid Biochemistry·D J LiberatoC H Shackleton
Apr 24, 1999·Journal of Mass Spectrometry : JMS·T M WilliamsD W Hill

❮ Previous
Next ❯

Citations

Feb 26, 2010·Journal of the American Society for Mass Spectrometry·Glenn A HarrisFacundo M Fernández
Oct 8, 2013·Rapid Communications in Mass Spectrometry : RCM·Cris LapthornFrank S Pullen
Aug 16, 2005·Prostaglandins & Other Lipid Mediators·Seon Hwa LeeIan A Blair
Dec 16, 2003·Rapid Communications in Mass Spectrometry : RCM·Christine M ThompsonCatriona Thom
Aug 19, 2004·Mass Spectrometry Reviews·Valérie Gabelica, Edwin De Pauw
Aug 28, 2001·Journal of Mass Spectrometry : JMS
Feb 26, 2009·Rapid Communications in Mass Spectrometry : RCM·Anton KaufmannDiana Uría
Sep 30, 2003·Rapid Communications in Mass Spectrometry : RCM·Seon Hwa LeeIan A Blair
Jul 20, 2021·Journal of the American Society for Mass Spectrometry·MyPhuong T LeR Graham Cooks

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Jun Yoshioka, Richard T Lee
© 2021 Meta ULC. All rights reserved