Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator andarine (S-4) for routine doping control purposes

Rapid Communications in Mass Spectrometry : RCM
Mario ThevisWilhelm Schänzer

Abstract

Selective androgen receptor modulators (SARMs) are potent anabolic agents with tissue-selective properties. Due to their potential misuse in elite sport, the World Anti-Doping Agency (WADA) has prohibited SARMs since 2008, and although no representative drug candidate has yet received full clinical approval, recent findings of SARMs illegally sold via the internet have further supported the need to efficiently test for these compounds in doping controls. In the present communication, the mass spectrometric characterization of urinary metabolites of the SARM Andarine (also referred to as S-4) compared with earlier in vitro and animal studies is reported. Liquid chromatography interfaced to high-resolution/high-accuracy (tandem) mass spectrometry was used to identify phase I and II metabolites, confirming the predicted target analytes for sports drug testing purposes including the glucuronic acid conjugates of the active drug, its monohydroxylated and/or deacetylated product, the hydrolysis product resulting from the removal of the compound's B-ring, as well as the sulfate of the monohydroxylated and the deacetylated phase I metabolite. The obtained data will support future efforts to effectively screen for and confirm the misuse...Continue Reading

References

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Feb 14, 2006·Rapid Communications in Mass Spectrometry : RCM·Mario ThevisWilhelm Schänzer
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Nov 7, 2007·Rapid Communications in Mass Spectrometry : RCM·Mario ThevisWilhelm Schänzer
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Citations

Mar 23, 2011·Analytical and Bioanalytical Chemistry·Mario ThevisWilhelm Schänzer
Feb 22, 2012·Analytical and Bioanalytical Chemistry·Markus R Meyer, Hans H Maurer
Jul 26, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Eva de RijkeSaskia S Sterk
Jun 8, 2014·Journal of Pharmaceutical and Biomedical Analysis·Mario Thevis, Wilhelm Schänzer
Jan 16, 2016·Drug Testing and Analysis·Lore GeldofKoen Deventer
Aug 6, 2011·Forensic Science International : Synergy·Elia GrataNorbert Baume
Jan 22, 2011·Drug Testing and Analysis·Mario ThevisWilhelm Schänzer
Feb 22, 2013·Drug Testing and Analysis·Borislav StarcevicAnthony W Butch
Mar 6, 2015·Drug Testing and Analysis·Bradley J StevensonMalcolm D McLeod
Nov 17, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Axel RydevikMikael Hedeland
Jan 9, 2019·Journal of the American Society for Mass Spectrometry·Fred A M G van GeenenMichel W F Nielen
Feb 26, 2019·Chembiochem : a European Journal of Chemical Biology·Mario S P CorreiaDaniel Globisch
Nov 18, 2019·Biomedical Chromatography : BMC·Azamat TemerdashevElina Gashimova
Jul 28, 2015·Mass Spectrometry Reviews·Wilhelm Schänzer, Mario Thevis
Aug 28, 2020·Drug Testing and Analysis·Yat-Ming SoEmmie N M Ho
Jan 11, 2018·Organic & Biomolecular Chemistry·Neeraj GargDaniel Globisch
Aug 15, 2021·Journal of Pharmaceutical and Biomedical Analysis·Mario ThevisAndreas Thomas

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