Mass spectrometric imaging of highly curved membranes during Tetrahymena mating

Science
Sara G OstrowskiAndrew G Ewing

Abstract

Biological membrane fusion is crucial to numerous cellular events, including sexual reproduction and exocytosis. Here, mass spectrometry images demonstrate that the low-curvature lipid phosphatidylcholine is diminished in the membrane regions between fusing Tetrahymena, where a multitude of highly curved fusion pores exist. Additionally, mass spectra and principal component analysis indicate that the fusion region contains elevated amounts of 2-aminoethylphosphonolipid, a high-curvature lipid. This evidence suggests that biological fusion involves and might in fact be driven by a heterogeneous redistribution of lipids at the fusion site.

References

May 31, 1977·Biochimica Et Biophysica Acta·G A Thompson, Y Nozawa
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S M Gruner
May 1, 1972·The Journal of protozoology·G A Thompson
Jul 15, 1996·Chemistry and Physics of Lipids·L Chernomordik
Jun 5, 1997·Nature·K Simons, E Ikonen
Jul 1, 1997·Analytical Chemistry·T L ColliverN Winograd
Oct 17, 1998·Rapid Communications in Mass Spectrometry : RCM·M L PacholskiN Winograd
Mar 1, 2000·Analytical Chemistry·S ChandraG H Morrison
Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M HaoF R Maxfield
Aug 30, 2002·Analytical Chemistry·Thomas P RoddyAndrew G Ewing
Sep 14, 2002·Science·Lin Yang, Huey W Huang
Jan 9, 2003·Chemical Reviews·Robert BlumenthalRichard M Epand
Aug 14, 2003·Biochimica Et Biophysica Acta·Gary Eitzen
May 1, 1982·Journal of Morphology·Jason Wolfe

❮ Previous
Next ❯

Citations

Nov 12, 2005·Analytical and Bioanalytical Chemistry·Zhong GuoLin He
Jun 2, 2005·Analytical and Bioanalytical Chemistry·Karen J OlsonEdgar A Arriaga
Aug 12, 2009·Analytical and Bioanalytical Chemistry·John S Fletcher, John C Vickerman
Jul 27, 2011·Analytical and Bioanalytical Chemistry·Allison L DillR Graham Cooks
Oct 29, 2010·Histochemistry and Cell Biology·Jaroslav PólMichael Volný
May 9, 2013·Histochemistry and Cell Biology·Andreas Römpp, Bernhard Spengler
Jun 11, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yuki Sugiura, Mitsutoshi Setou
Apr 8, 2011·Journal of the American Society for Mass Spectrometry·John J BradyRobert J Levis
Aug 30, 2012·Journal of the American Society for Mass Spectrometry·Kevin R TuckerJonathan V Sweedler
Oct 15, 2013·Analytica Chimica Acta·Karel Klepárník, František Foret
May 26, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Gianluca MaddaloGiorgio Federici
Oct 18, 2008·Journal of the American Society for Mass Spectrometry·Qiang LiuLin He
Mar 12, 2010·Journal of the American Society for Mass Spectrometry·Michael E KurczyAndrew G Ewing
Mar 11, 2011·Analytical Chemistry·Bindesh ShresthaAkos Vertes
Jan 21, 2011·Analytical Chemistry·He WangZheng Ouyang
Jun 23, 2011·Analytical Chemistry·Tyler A ZimmermanEdwin De Pauw
Oct 25, 2011·Analytical Chemistry·Kevin R TuckerJonathan V Sweedler
Nov 23, 2011·Analytical Chemistry·Jiangjiang LiuZheng Ouyang
Jul 24, 2012·Analytical Chemistry·Yvonne SchoberAndreas Römpp
Nov 14, 2012·Analytical Chemistry·Jay G ForsytheJohn A McLean
Oct 26, 2012·Analytical Chemistry·John S Fletcher, John C Vickerman
Oct 18, 2013·Analytical Chemistry·Jeremy BrisonDavid G Castner
Oct 18, 2008·Analytical Chemistry·Paul D PiehowskiAndrew G Ewing
Mar 28, 2013·ACS Chemical Neuroscience·Jörg HanriederAndrew G Ewing
Nov 30, 2007·Journal of the American Chemical Society·Leiliang ZhengNicholas Winograd
Jun 24, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Paul D PiehowskiAndrew G Ewing
Aug 20, 2009·Nature Chemical Biology·H Alex Brown, Robert C Murphy
Mar 8, 2008·Nature Protocols·Justin M WisemanR Graham Cooks
Mar 2, 2005·Nature Reviews. Microbiology·Esther R Angert
Oct 20, 2009·The Analyst·John S Fletcher
Apr 10, 2010·Physical Chemistry Chemical Physics : PCCP·Asad RezaeeSilvia Mittler
Jan 15, 2013·The Analyst·David Gode, Dietrich A Volmer
Jul 18, 2012·Chemical Communications : Chem Comm·Pamela V Chang, Carolyn R Bertozzi
Jul 31, 2013·The Analyst·Pengyuan LiuHao Chen
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marzuk M KamalJonathon Howard
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael E KurczyAndrew G Ewing
Nov 27, 2010·Journal of Electron Microscopy·Mitsutoshi Setou, Nobuya Kurabe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Michael E KurczyAndrew G Ewing
Langmuir : the ACS Journal of Surfaces and Colloids
Paul D PiehowskiAndrew G Ewing
Analytical Chemistry
Peter SjövallBjörn Johansson
© 2022 Meta ULC. All rights reserved