Mass spectrometric methods for monitoring redox processes in electrochemical cells

Mass Spectrometry Reviews
Herbert OberacherSabine Plattner

Abstract

Electrochemistry (EC) is a mature scientific discipline aimed to study the movement of electrons in an oxidation-reduction reaction. EC covers techniques that use a measurement of potential, charge, or current to determine the concentration or the chemical reactivity of analytes. The electrical signal is directly converted into chemical information. For in-depth characterization of complex electrochemical reactions involving the formation of diverse intermediates, products and byproducts, EC is usually combined with other analytical techniques, and particularly the hyphenation of EC with mass spectrometry (MS) has found broad applicability. The analysis of gases and volatile intermediates and products formed at electrode surfaces is enabled by differential electrochemical mass spectrometry (DEMS). In DEMS an electrochemical cell is sampled with a membrane interface for electron ionization (EI)-MS. The chemical space amenable to EC/MS (i.e., bioorganic molecules including proteins, peptides, nucleic acids, and drugs) was significantly increased by employing electrospray ionization (ESI)-MS. In the simplest setup, the EC of the ESI process is used to analytical advantage. A limitation of this approach is, however, its inability t...Continue Reading

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Citations

Sep 29, 2015·Rapid Communications in Mass Spectrometry : RCM·Caiming TangXianzhi Peng
Aug 28, 2015·Journal of the American Society for Mass Spectrometry·Yao-Min Liu, Richard H Perry
Apr 16, 2016·Future Medicinal Chemistry·Lixia Gao, Yong Teng
Oct 6, 2016·The Analyst·Shuting XuHuwei Liu
Apr 30, 2017·Journal of Mass Spectrometry : JMS·S BeckM W Linscheid
Aug 26, 2018·International Journal of Molecular Sciences·Laura Navarro SuarezSascha Rohn
Jan 9, 2018·Chemical Society Reviews·Alok M TripathiBing Joe Hwang
Oct 7, 2014·Chemical Research in Toxicology·Ugo Bussy, Mohammed Boujtita

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Methods Mentioned

BETA
quartz crystal microbalance
electrophoresis
chip

Software Mentioned

DEMS

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