Mass spectrometry imaging of amino neurotransmitters: a comparison of derivatization methods and application in mouse brain tissue

Metabolomics : Official Journal of the Metabolomic Society
Clara EsteveLiam A McDonnell

Abstract

The detection of small polar compounds such as amino neurotransmitters by MALDI mass spectrometry imaging has been hindered by low-detection sensitivity and background interferences. Recently, several of on-tissue chemical derivatization strategies have been independently reported that enable their detection. Here, we present a comparison between these methods, and demonstrate the visualization of the distributions of up to 23 amino metabolites in tissue. We applied this methodology to detect alterations of these compounds after inducing an experimental cortical spreading depression in mouse brain, which causes profound transient alterations in key neurotransmitters in one hemisphere and is relevant for migraine and various other neurological disorders.

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Citations

Oct 1, 2016·Current Opinion in Biotechnology·Teesha C BakerChristoph H Borchers
Nov 1, 2016·Journal of the American Society for Mass Spectrometry·Anna Maria A P FernandesMarcos N Eberlin
Sep 12, 2018·Expert Review of Proteomics·Marialaura DililloLiam A McDonnell
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Nov 6, 2018·The Journal of Comparative Neurology·Guang Xu, Jianjun Li
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Sep 25, 2019·Nature Methods·Mohammadreza ShariatgorjiPer E Andrén
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Apr 30, 2020·Metabolites·Joseph S MillerKevin V Hackshaw
Nov 10, 2020·Mass Spectrometry Reviews·Kellen DeLaneyLingjun Li
Jan 13, 2021·Mass Spectrometry Reviews·Carla HarkinDiego F Cobice
Feb 10, 2021·Critical Reviews in Analytical Chemistry·Vladimir G Zaikin, Roman S Borisov
Nov 21, 2020·Analytical and Bioanalytical Chemistry·Qiuqin ZhouCarsten Hopf
Jan 17, 2021·Experimental and Molecular Pathology·Kevin ZemaitisVijaya Prakash Krishnan Muthaiah
Feb 26, 2021·Journal of Mass Spectrometry : JMS·Trevor T ForsmanYoung Jin Lee
Oct 26, 2020·Journal of Chemical Neuroanatomy·Fumihiro EtoKohji Sato
Aug 5, 2021·Metabolic Brain Disease·Laura K SchnackenbergE Ellen Jones
Jul 16, 2020·Analytical Chemistry·Elizabeth K NeumannJeffrey M Spraggins
Nov 6, 2021·AJNR. American Journal of Neuroradiology·S EkiciC C Fleischer

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Software Mentioned

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