Mass spectrometry imaging reveals heterogeneous efavirenz distribution within putative HIV reservoirs

Antimicrobial Agents and Chemotherapy
Corbin G ThompsonElias P Rosen

Abstract

Persistent HIV replication within active viral reservoirs may be caused by inadequate antiretroviral penetration. Here, we used mass spectrometry imaging with infrared matrix-assisted laser desorption-electrospray ionization to quantify the distribution of efavirenz within tissues from a macaque dosed orally to a steady state. Intratissue efavirenz distribution was heterogeneous, with the drug concentrating in the lamina propria of the colon, the primary follicles of lymph nodes, and the brain gray matter. These are the first imaging data of an antiretroviral drug in active viral reservoirs.

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Citations

Sep 29, 2015·Analytical Chemistry·Elias P RosenDavid C Muddiman
Aug 21, 2016·Toxicology Letters·Nádia M GriloSofia A Pereira
Apr 12, 2017·AIDS Research and Human Retroviruses·Corbin G ThompsonAngela D M Kashuba
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Jun 8, 2017·AIDS·Corbin G ThompsonAngela D M Kashuba
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Nov 2, 2016·Antimicrobial Agents and Chemotherapy·Paul CurleyMarco Siccardi
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Oct 16, 2019·Antimicrobial Agents and Chemotherapy·Aaron S DevanathanAngela D M Kashuba
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Jul 15, 2020·Antimicrobial Agents and Chemotherapy·Aaron S DevanathanAngela D M Kashuba
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