Mass spectrometry in biodefense

Journal of Mass Spectrometry : JMS
P A Demirev, C Fenselau

Abstract

Potential agents for biological attacks include both microorganisms and toxins. In mass spectrometry (MS), rapid identification of potential bioagents is achieved by detecting the masses of unique biomarkers, correlated to each agent. Currently, proteins are the most reliable biomarkers for detection and characterization of both microorganisms and toxins, and MS-based proteomics is particularly well suited for biodefense applications. Confident identification of an organism can be achieved by top-down proteomics following identification of individual protein biomarkers from their tandem mass spectra. In bottom-up proteomics, rapid digestion of intact protein biomarkers is again followed by MS/MS to provide unambiguous bioagent identification and characterization. Bioinformatics obviates the need for culturing and rigorous control of experimental variables to create and use MS fingerprint libraries for various classes of bioweapons. For specific applications, MS methods, instruments and algorithms have also been developed for identification based on biomarkers other than proteins and peptides.

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Citations

Apr 10, 2013·Journal of the American Society for Mass Spectrometry·Plamen A DemirevAndrew B Feldman
Jun 1, 2013·Journal of the American Society for Mass Spectrometry·Catherine C Fenselau
Jan 17, 2012·Analytical Chemistry·Dan LiMilton L Lee
Nov 9, 2012·Analytical Chemistry·Vladimir HavlicekKevin A Schug
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Aug 3, 2014·Journal of Proteomics·Valérie LabasElisabeth Blesbois
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Sep 22, 2012·Mass Spectrometry Reviews·Todd R SandrinStephanie Schumaker
Jul 30, 2020·Mass Spectrometry Reviews·Kenyon Evans-NguyenChristopher C Mulligan
Jun 16, 2009·Analytical Chemistry·Elodie DuriezEric Ezan
Nov 4, 2009·Analytical Chemistry·Colin WynneNathan Edwards
Jul 20, 2016·Journal of Proteome Research·Stefanie PfrunderDavid Drissner

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