Mass spectrometry in drug metabolism and pharmacokinetics: Current trends and future perspectives

Rapid Communications in Mass Spectrometry : RCM
Filip Cuyckens

Abstract

Drug Metabolism and Pharmacokinetics (DMPK) is a core scientific discipline within drug discovery and development as well as post-marketing. It helps to design and select the most promising drug candidate and obtain advanced insights on the processes that control absorption, distribution, metabolism and excretion (ADME) of the final drug candidate. Mass spectrometry is one of the key technologies applied in DMPK. Therefore, the continuous advances made in the field of mass spectrometry also directly impact the way in which we investigate the ADME properties of a compound, providing us with new tools to gather more information or improve our efficiency. An overview will be given of some important current trends and future perspectives in the field.

References

Jul 25, 2009·Mass Spectrometry Reviews·Thomas R CoveyBradley B Schneider
Oct 14, 2010·Rapid Communications in Mass Spectrometry : RCM·Gordon J DearIain Campuzano
Nov 19, 2011·Rapid Communications in Mass Spectrometry : RCM·Filip CuyckensJan Claereboudt
Mar 14, 2012·Bioanalysis·Filip CuyckensRussell J Mortishire-Smith
Jun 1, 2013·Bioanalysis·Lieve Dillen, Filip Cuyckens
Nov 28, 2013·Analytical and Bioanalytical Chemistry·Shane R EllisRon M A Heeren
Nov 22, 2014·Bioanalysis·Guillaume HochartJonathan Stauber
Feb 3, 2015·Drug Metabolism Reviews·Bo Wen, Mingshe Zhu
Jul 15, 2015·Analytical and Bioanalytical Chemistry·Andreas LimbeckFrank Vanhaecke
Jul 28, 2017·Journal of Mass Spectrometry : JMS·Adam P CismesiaNicolas C Polfer

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Citations

Nov 11, 2018·Rapid Communications in Mass Spectrometry : RCM·Paul Trevorrow, David P A Kilgour
May 30, 2020·Rapid Communications in Mass Spectrometry : RCM·Dominik BrechtOliver J Schmitz
Jun 25, 2020·Advanced Drug Delivery Reviews·Patrick M GlassmanVladimir R Muzykantov
Mar 20, 2021·Analytica Chimica Acta·Dylan H Ross, Libin Xu
May 25, 2021·Journal of the American Society for Mass Spectrometry·Jixia YangHongliang Wen
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Robert SkibińskiMaciej Gawlik
Jul 1, 2021·Journal of the American Society for Mass Spectrometry·Jingwei Cai, Zhengyin Yan
Jul 27, 2021·Drug Metabolism Reviews·Aarzoo ThakurChukwunonso K Nwabufo
Oct 6, 2021·Analytical Methods : Advancing Methods and Applications·Klim A LeonovVladimir V Udut
Oct 9, 2021·Scientific Reports·João Paulo Almirão de JesusFelipe de Almeida La Porta

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