Mass spectrometry in toxinology: a 21st-century technology for the study of biopolymers from venoms

Toxicon : Official Journal of the International Society on Toxinology
P Escoubas

Abstract

Mass spectrometry, developed in the early days of the 20th century for the structural analysis of ions from organic compounds, has evolved from an analytical technique almost entirely applied to structural studies of small molecules, to a diversified technology that is now increasingly focused on the study of biological macromolecules. Novel instrument developments and appropriate ionization techniques have permitted the application of mass spectrometry to the analysis of biopolymers such as proteins, sugars and nucleic acids and have opened the door to a multiplicity of applications, and not the least being proteomics. Increasingly used as a basic analytical tool in biology laboratories, mass spectrometry has now found another niche of application in the field of venom and toxin studies. The technique is well suited to the analysis of peptide and protein components of venoms, be it for global mass mapping of complex mixtures or structural studies on individual toxins. Further enhanced by hyphenation with separation technologies, mass spectrometry is well adapted to de-convolve the extreme complexity of natural venoms and biological extracts in which toxinologists specialize. This special issue highlights a number of applicatio...Continue Reading

References

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Citations

Feb 13, 2009·Journal of Proteomics·Richard H ValenteGilberto B Domont
May 22, 2009·Journal of Proteomics·G P Espino-SolisL D Possani
Jun 21, 2007·Journal of Analytical Toxicology·Michael L SmithMarilyn A Huestis
Nov 18, 2011·Expert Review of Proteomics·Juan J Calvete
Oct 22, 2008·Expert Review of Proteomics·Songping Liang
Jun 1, 2007·Expert Opinion on Drug Discovery·Pierre Escoubas, Frank Bosmans
Jun 23, 2009·Peptides·Jasmine DavisRichard J Lewis
Jul 16, 2008·Toxicon : Official Journal of the International Society on Toxinology·Glenn F KingGraham M Nicholson
Oct 12, 2011·Journal of Proteomics·Pier Giorgio RighettiJuan J Calvete
Oct 24, 2007·Toxicon : Official Journal of the International Society on Toxinology·L H du PlessisJ L du Plessis
Feb 28, 2008·Journal of Mass Spectrometry : JMS·P EscoubasG M Nicholson
Jan 18, 2011·Toxicon : Official Journal of the International Society on Toxinology·Tiago Elias Heinen, Ana Beatriz Gorini da Veiga
Jun 25, 2013·Toxicon : Official Journal of the International Society on Toxinology·C C HortaE Kalapothakis
Feb 3, 2007·Natural Product Reports·Georgina EstradaGerardo Corzo
Oct 21, 2016·Integrative and Comparative Biology·Marymegan Daly, H Lisle Gibbs
Apr 21, 2007·Molecular & Cellular Proteomics : MCP·Nuno BandeiraPavel A Pevzner
May 27, 2017·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Hiroko KawakamiTetsuro Shinada
Nov 22, 2016·Toxicon : Official Journal of the International Society on Toxinology·Yazhou HuangZhonghua Liu

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