Mass spectrometry informs the structure and dynamics of membrane proteins involved in lipid and drug transport.

Current Opinion in Structural Biology
Jani R BollaCarol V Robinson

Abstract

Membrane proteins are important macromolecules that play crucial roles in many cellular and physiological processes. Over the past two decades, the use of mass spectrometry as a biophysical tool to characterise membrane proteins has grown steadily. By capturing these dynamic complexes in the gas phase, many unknown small molecule interactions have been revealed. One particular application of this research has been the focus on antibiotic resistance with considerable efforts being made to understand underlying mechanisms. Here we review recent advances in the application of mass spectrometry that have yielded both structural and dynamic information on the interactions of antibiotics with proteins involved in bacterial cell envelope biogenesis and drug efflux.

References

Jul 18, 2006·Nature Reviews. Microbiology·Laura J V Piddock
Dec 2, 2006·Nature Reviews. Drug Discovery·John P OveringtonAndrew L Hopkins
May 22, 2009·Nature·Stephen H White
Sep 8, 2009·Drug Discovery Today·Yalini ArinaminpathyMark B Gerstein
Sep 29, 2012·Environmental Microbiology·Salim T Islam, Joseph S Lam
Jul 31, 2013·Journal of the American Society for Mass Spectrometry·Carlo SantambrogioRita Grandori
Nov 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Karl A HassanIan T Paulsen
Jun 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Goran MalojčićDaniel Kahne
Mar 5, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jessica M A BlairLaura J V Piddock
May 15, 2015·Frontiers in Microbiology·Henrietta VenterShutao Ma
Aug 19, 2015·Current Opinion in Structural Biology·Dijun DuBen F Luisi
Mar 31, 2016·Nature Reviews. Microbiology·Suguru OkudaDaniel Kahne
Aug 25, 2016·Advances in Experimental Medicine and Biology·Lan ZhuWei Liu
Mar 5, 2017·Essays in Biochemistry·Mohsen Chitsaz, Melissa H Brown
Apr 11, 2017·Nature Structural & Molecular Biology·Qingshan LuoYihua Huang
Jun 24, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Joshua J ZiarekGerhard Wagner
Aug 10, 2017·Nature Communications·Haohao DongChangjiang Dong
Sep 10, 2017·Annual Review of Microbiology·Anna KonovalovaThomas J Silhavy
Dec 19, 2017·Cell·Alexander S HauserM Madan Babu
Feb 24, 2018·Nature Reviews. Drug Discovery·Tudor I OpreaGergely Zahoránszky-Köhalmi
Mar 7, 2018·Methods : a Companion to Methods in Enzymology·Antonio N Calabrese, Sheena E Radford
Jul 14, 2018·Nature Reviews. Microbiology·Dijun DuBen F Luisi
Jan 17, 2019·Biochemical Society Transactions·Timothy M Allison, Cherine Bechara
Feb 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Carol V Robinson
Feb 26, 2019·Chemistry and Physics of Lipids·Michelle RedhairWilliam M Atkins
Mar 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Márió Gajdács
Mar 13, 2019·Current Opinion in Structural Biology·Jörg Standfuss
Mar 23, 2019·Annual Review of Biochemistry·Jani Reddy BollaCarol V Robinson
Apr 7, 2019·Chemistry and Physics of Lipids·Melissa Frick, Carla Schmidt
Aug 4, 2019·Research in Microbiology·Paola SperandeoAlessandra Polissi
Aug 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Karl A HassanIan T Paulsen
Aug 20, 2019·The Journal of Biological Chemistry·Rahul Shrivastava, Shu-Sin Chng
Mar 5, 2020·Biochemical Society Transactions·Cagla SahinMichael Landreh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved