PMID: 2490371Jan 1, 1989Paper

Mass spectrometry of beta-lactam antibiotics with special reference to ionization by fast atom bombardment (FAB)

Journal of Pharmaceutical and Biomedical Analysis
A F CasyE M Ominde

Abstract

The mass spectral characteristics of the majority of penicillin and cephalosporin beta-lactam antibiotics in world-wide clinical use are presented and reviewed. Special attention is given to the spectra recorded under fast atom bombardment (FAB) conditions and novel data on many penicillins and cephalosporins are included. Mass spectrometry features of common degradation products of benzylpenicillin and of some synthetic intermediates are also presented. The data illustrate the value of FAB mass spectrometry in identifying members of this closely related group of antibiotics without need for derivatization.

Citations

Mar 3, 1996·Journal of Chromatography. B, Biomedical Applications·K KobayashiY Katsumata
Sep 1, 1994·Journal of Pharmaceutical and Biomedical Analysis·Y ZhuJ Hoogmartens
Jan 27, 1999·Journal of Pharmaceutical and Biomedical Analysis·S Eric-JovanovicS Vladimirov
Jan 1, 1991·Critical Reviews in Biotechnology·C M Franco, L E Coutinho
Jan 1, 1995·Rapid Communications in Mass Spectrometry : RCM·A Triolo, F Bonelli
Jun 17, 2010·Rapid Communications in Mass Spectrometry : RCM·Jin LiChang-qin Hu
Dec 15, 2010·Rapid Communications in Mass Spectrometry : RCM·Hsin-Pin HoMaw-Rong Lee

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