Mass transport and shear stress in a microchannel bioreactor: numerical simulation and dynamic similarity

Journal of Biomechanical Engineering
Y ZengHong Tong Low

Abstract

Microchannel bioreactors have been used in many studies to manipulate and investigate the fluid microenvironment around cells. In this study, substrate concentrations and shear stresses at the base were computed from a three-dimensional numerical flow-model incorporating mass transport. Combined dimensionless parameters were developed from a simplified analysis. The numerical results of substrate concentration were well correlated by the combined parameters. The generalized results may find applications in design analysis of microchannel bioreactors. The mass transport and shear stress were related in a generalized result. Based on the generalized results and the condition of dynamic similarity, various means to isolate their respective effects on cells were considered.

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Citations

Feb 25, 2010·Chemical Society Reviews·Edmond W K Young, David J Beebe
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jonathan W Song, Lance L Munn
Jun 1, 2007·Journal of Biomechanical Engineering·Yan ZengHong-Tong Low
Jun 6, 2008·Journal of Biomechanical Engineering·Yan ZengHong-Tong Low
Oct 5, 2010·Journal of Biomechanical Engineering·Xiao Bing ChenHong Tong Low
Feb 22, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Jay W WarrickDavid J Beebe
Sep 4, 2013·BioMed Research International·Nasim Salehi-NikBehrouz Zandieh-Doulabi
Dec 7, 2013·Biotechnology and Bioengineering·Myat Noe HsuHwa Liang Leo
May 4, 2007·Lab on a Chip·Natanel KorinShulamit Levenberg
Nov 1, 2008·Biotechnology and Bioengineering·Natanel KorinShulamit Levenberg
Jun 26, 2012·Biomedical Microdevices·Zhouchun HuangYuxin Liu
May 13, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Ke LiuDimitri Pappas

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