Massive crossover elevation via combination of HEI10 and recq4a recq4b during Arabidopsis meiosis.

Proceedings of the National Academy of Sciences of the United States of America
Heïdi SerraIan R Henderson

Abstract

During meiosis, homologous chromosomes undergo reciprocal crossovers, which generate genetic diversity and underpin classical crop improvement. Meiotic recombination initiates from DNA double-strand breaks (DSBs), which are processed into single-stranded DNA that can invade a homologous chromosome. The resulting joint molecules can ultimately be resolved as crossovers. In Arabidopsis, competing pathways balance the repair of ∼100-200 meiotic DSBs into ∼10 crossovers per meiosis, with the excess DSBs repaired as noncrossovers. To bias DSB repair toward crossovers, we simultaneously increased dosage of the procrossover E3 ligase gene HEI10 and introduced mutations in the anticrossovers helicase genes RECQ4A and RECQ4B As HEI10 and recq4a recq4b increase interfering and noninterfering crossover pathways, respectively, they combine additively to yield a massive meiotic recombination increase. Interestingly, we also show that increased HEI10 dosage increases crossover coincidence, which indicates an effect on interference. We also show that patterns of interhomolog polymorphism and heterochromatin drive recombination increases distally towards the subtelomeres in both HEI10 and recq4a recq4b backgrounds, while the centromeres remain...Continue Reading

References

Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·S Keeney, N Kleckner
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·G P CopenhaverD Preuss
Feb 13, 2003·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·E. Esch, E. Weber
Aug 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nancy KlecknerJohn Hutchinson
Jul 28, 2005·The Plant Journal : for Cell and Molecular Biology·Cathy Melamed-BessudoAvraham A Levy
Nov 29, 2005·EMBO Reports·Eyal EmmanuelAvraham A Levy
May 4, 2006·Nucleic Acids Research·Csanád Z BachratiIan D Hickson
Jul 29, 2006·Cell·Gareth H Jones, F Chris H Franklin
Sep 6, 2007·Genes & Development·Eugenio Sanchez-MoranF Christopher H Franklin
Nov 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Frank HartungHolger Puchta
Feb 10, 2010·Nature Reviews. Genetics·Julie A Law, Steven E Jacobsen
Oct 12, 2010·Nature Structural & Molecular Biology·Petr CejkaStephen C Kowalczykowski
Jan 27, 2011·The Plant Journal : for Cell and Molecular Biology·James D HigginsF Christopher H Franklin
Oct 18, 2011·Nature·Valerie GarciaMatthew J Neale
Jun 23, 2012·Science·Wayne CrismaniRaphaël Mercier
Jul 14, 2012·PLoS Genetics·Kejian WangZhukuan Cheng
Jul 31, 2012·PLoS Genetics·Liudmila ChelyshevaMathilde Grelon
Aug 5, 2014·Annual Review of Genetics·James D HigginsF Chris H Franklin
Dec 11, 2014·Annual Review of Plant Biology·Raphaël MercierMathilde Grelon
Jan 15, 2015·G3 : Genes - Genomes - Genetics·Beth A RowanKorbinian Schneeberger
Apr 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Mathilde Séguéla-ArnaudRaphael Mercier
Oct 30, 2015·Cold Spring Harbor Perspectives in Biology·Neil Hunter
Nov 11, 2015·Proceedings of the National Academy of Sciences of the United States of America·Qing LiNathan M Springer
May 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Eli Rodgers-MelnickEdward S Buckler
Jun 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Luis ZapataKorbinian Schneeberger
Jul 16, 2016·PLoS Genetics·Kyuha ChoiIan R Henderson
Sep 21, 2016·Annual Review of Genetics·Stephen Gray, Paula E Cohen
Dec 15, 2016·Nucleic Acids Research·Mathilde Séguéla-ArnaudRaphael Mercier
Jan 7, 2017·Science·Eleni P MimitouScott Keeney

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Citations

Sep 5, 2019·Plant Biotechnology Journal·Ruud A de MaagdYuling Bai
Aug 6, 2019·The Plant Journal : for Cell and Molecular Biology·Felix Wolter, Holger Puchta
Sep 20, 2019·The Plant Journal : for Cell and Molecular Biology·Eun-Cheon LimKyuha Choi
Sep 17, 2020·The EMBO Journal·Alexander R BlackwellIan R Henderson
Sep 22, 2019·Nature Communications·Hequan SunKorbinian Schneeberger
Oct 3, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yafei LiZhukuan Cheng
Nov 28, 2018·Nature Plants·Delphine MieuletRaphael Mercier
Jun 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Christophe LambingIan R Henderson
Jan 9, 2019·Frontiers in Genetics·Julia DluzewskaPiotr A Ziolkowski
Aug 2, 2019·Heredity·April L PetersonBret A Payseur
Jul 14, 2018·Frontiers in Plant Science·Alexandre PeléAnne-Marie Chèvre
Mar 21, 2019·Frontiers in Plant Science·Pablo Bolaños-Villegas, Orlando Argüello-Miranda
May 10, 2019·The Arabidopsis Book·Pablo Bolaños-VillegasaYingxiang Wang
Jun 15, 2019·Plant Biotechnology Journal·Ian FayosEmmanuel Guiderdoni
Jan 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Carl VellerMartin A Nowak
Jul 5, 2018·Frontiers in Plant Science·Christophe Lambing, Stefan Heckmann
Jan 22, 2020·Trends in Plant Science·Ella TaagenMark E Sorrells
Mar 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Laia Capilla-PérezRaphael Mercier
Mar 23, 2021·Genetics, Selection, Evolution : GSE·Elise TourretteOlivier C Martin
Apr 6, 2019·Trends in Genetics : TIG·Mateusz ZelkowskiWojtek Pawlowski
Apr 14, 2021·Nature Plants·Divyashree C NageswaranIan R Henderson
Apr 25, 2021·Trends in Plant Science·Matthew ReynoldsPeter E Wittich
Apr 27, 2021·Frontiers in Plant Science·Jamie N OrrIsabelle Colas
May 8, 2021·Nature Plants·Michelle RönspiesHolger Puchta
Aug 6, 2021·Frontiers in Plant Science·Pallas KuoChristophe Lambing
Aug 14, 2021·Proceedings of the National Academy of Sciences of the United States of America·Longfei ZhuPiotr A Ziolkowski
Nov 12, 2021·Science·Matthew NaishIan R Henderson
Jul 27, 2021·Annual Review of Genetics·Ian R Henderson, Kirsten Bomblies

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