PMID: 3743844Jan 1, 1986Paper

Massive lymphocyte-mediated apoptosis during the early stage of pseudopelade

Dermatologica
C Pierard-Franchimont, G E Pierard

Abstract

The early evolving lesions of the hair follicles are described in pseudopelade, a type of cicatricial alopecia where clues for the diagnosis of lupus erythematosus or lichen plano-pilaris are lacking. A sudden and synchronized cell death of all the cells of the epithelial sheaths of the hair follicles occurs and is associated with a dense infiltration by lymphocytes. The epidermis remains uninvolved. This unique aspect is most probably related to the mechanism of apoptosis. Its intensity and extension are much more pronounced than in lichen planus and in lupus erythematosus. Pathogenesis of at least some cicatricial alopecias could therefore be related to massive apoptosis without evident and close relationship with the classical etiologies, i.e. lichen planus and lupus erythematosus.

Citations

Apr 1, 1994·Journal of Cutaneous Pathology·S F Templeton, A R Solomon
Feb 1, 1993·Experimental Dermatology·R PausB M Czarnetzki
Aug 10, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Stefan Trachsler, Ralph M Trueb
Jun 22, 2010·Expert Opinion on Biological Therapy·Gérald E PiérardPascale Quatresooz
Oct 29, 2013·Clinics in Dermatology·Marcia Ramos-e-Silva, Rodrigo Pirmez
May 21, 2008·International Journal of Cosmetic Science·P QuatresoozG E Piérard
Aug 22, 2008·Dermatologic Therapy·Abdullateef A AlzolibaniJerry Shapiro
Apr 21, 2004·Journal of the American Academy of Dermatology·Atsushi AkagiAkira Ishibashi
Jun 21, 2005·Journal of the American Academy of Dermatology·Elizabeth K RossJerry Shapiro
Nov 29, 2005·Clinical and Experimental Dermatology·C Piérard-FranchimontG E Piérard
Feb 26, 2016·The American Journal of Dermatopathology·Julien LanoueRobert G Phelps

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