PMID: 8971116Dec 1, 1996Paper

Massive nerve root enlargement in chronic inflammatory demyelinating polyneuropathy

Journal of Neurology, Neurosurgery, and Psychiatry
W SchadyC M Smith

Abstract

To report three patients with chronic inflammatory demyelinating polyneuropathy (CIDP) presenting with symptoms suggestive of cervical (one patient) and lumbar root disease. Nerve conduction studies, EMG, and nerve biopsy were carried out, having found the nerve roots to be very enlarged on MRI, CT myelography, and at surgery. Clinically, peripheral nerve thickening was slight or absent. Subsequently one patient developed facial nerve hypertrophy. This was mistaken for an inner ear tumour and biopsied, with consequent facial palsy. Neurophysiological tests suggested a demyelinating polyneuropathy. Sural nerve biopsy showed in all cases some loss of myelinated fibres, inflammatory cell infiltration, and a few onion bulbs. Hypertrophic changes were much more prominent on posterior nerve root biopsy in one patient: many fibres were surrounded by several layers of Schwann cell cytoplasm. There was an excellent response to steroids in two patients but not in the third (most advanced) patient, who has benefited only marginally from intravenous immunoglobulin therapy. MRI of the cauda equina may be a useful adjunct in the diagnosis of CIDP.

References

Jun 1, 1976·Journal of the Neurological Sciences·G A De León, F J Hodges
Sep 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·S H HawkeJ G McLeod
Oct 1, 1983·Neurology·N L Rosenberg, D Bourdette
Aug 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·L GinsbergP K Thomas
Feb 1, 1994·Muscle & Nerve·R N De SilvaA M Thomas

❮ Previous
Next ❯

Citations

Jul 25, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·H S GoedeeL H Visser
Mar 31, 2004·Journal of the Neurological Sciences·Naoki MatsuokaMasayasu Matsumoto
Jul 2, 1999·Brain : a Journal of Neurology·A J DugginsJ R Soper
Jun 17, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·C M EllisP N Leigh
Jan 28, 2004·Neurosurgery·Ryan M KretzerRafael J Tamargo
Jul 17, 2001·Journal of Neurosurgery·C Pérez-LópezA Isla
Dec 14, 1999·Journal of the Neurological Sciences·G MidroniJ Vajsar
Nov 4, 2016·British Journal of Neurosurgery·Hong Kyung ShinSang Ryong Jeon
Nov 11, 2009·Journal of the Neurological Sciences·Hideyuki MatsumotoYoshikazu Ugawa
Feb 9, 2007·Journal of the Neurological Sciences·S BoukhrisJ-M Vallat
May 25, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H S GoedeeL H Visser
Nov 25, 2014·Journal of the Peripheral Nervous System : JPNS·Alexander GrimmHubertus Axer
Jan 24, 2006·Neuromuscular Disorders : NMD·Lloyd J BradleyRichard W Orrell
Jun 22, 2005·European Journal of Internal Medicine·Kazuhiro IshiiShin'ichi Shoji
Mar 19, 2014·Muscle & Nerve·Alexander GrimmHubertus Axer
Dec 17, 2008·Physical Medicine and Rehabilitation Clinics of North America·Kevin Busche
Sep 21, 2005·Arquivos de neuro-psiquiatria·Marcos R G de FreitasRomeu Cortes Domingues
Nov 26, 2003·Muscle & Nerve·Steve VucicDidier Cros
Sep 20, 2016·British Journal of Hospital Medicine·Fu Liong HiewYusuf A Rajabally
Aug 9, 2017·Muscle & Nerve·Stéphane MathisGwendal Le Masson
Jul 22, 2004·Muscle & Nerve·Roy BeekmanLeonard H Van Den Berg
Mar 29, 2005·Muscle & Nerve·Dianna QuanB K Kleinschmidt-Demasters
Oct 2, 2019·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Kevin J GilmoreCharles L Rice
Dec 16, 1998·Current Opinion in Neurology·H P HartungJ D Pollard
Jan 1, 2016·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Christopher D FrischMatthew L Carlson
Aug 12, 2020·Rinshō shinkeigaku = Clinical neurology·Toshihiko MaedaTakashi Kanda
Aug 2, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H S GoedeeL H van den Berg
Mar 27, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Edyta DziadkowiakMagdalena Koszewicz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.