PMID: 2508601Jul 1, 1989Paper

Massive poisoning by naftidrofuryl with severe disorders of rhythm and conduction

Archives des maladies du coeur et des vaisseaux
J L ReyP Bernasconi

Abstract

The authors report the case of a 35-year old woman with normal heart who voluntarily poisoned herself by swallowing 6 grams of naftidrofuryl. She developed disorders of atrioventricular conduction and a ventricular-like arrhythmia with collapse which resolves after mechanical ventilation. Data from the literature indicate that naftidrofuryl possesses class I electrophysiological properties which must not be ignored and which account for the cardiac effects observed in this particular case and in cases of parenteral overdosage already reported. By analogy with class I antiarrhythmic agents, treatment of naftidrofuryl poisoning with disorders of conduction could include the administration of molar sodium lactate.

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Related Papers

Annales de cardiologie et d'angéiologie
G DuclouxM Delecour
Morphologiai és igazságügyi orvosi szemle
Z Szabö, G Prinz
Archiwum medycyny sa̧dowej i kryminologii
Anna Niemcunowicz-JanicaIwona Ptaszyńska-Sarosiek
Postgraduate Medical Journal
J S de Caestecker, R C Heading
Journal de gynécologie, obstétrique et biologie de la reproduction
T RoutiotP Barbarino-Monnier
© 2022 Meta ULC. All rights reserved