Massive transfusion as a risk factor for acute lung injury: association or causation?

Critical Care Medicine
Avery B Nathens

Abstract

One of the most common clinical sequelae of massive transfusion is acute lung injury. In virtually all clinical settings, there is a very strong relationship between transfusion and acute lung injury that remains even after adjusting for potential confounders. Whether the association between transfusion and acute lung injury in these settings is a result of residual confounding or actually reflects a causal relationship is unknown. However, there are several potential mechanisms by which massive transfusion might predispose to lung injury: a) cognate antigen-antibody interactions (classic transfusion-associated lung injury); b) activation of nonspecific immunity through soluble mediators present in transfused blood; c) an increased risk of infection through transfusion-associated immunomodulation leading to sepsis and sepsis-induced lung injury; and d) volume overload in the face of increased permeability of the alveolar capillary membrane. Elucidating the precise causal mechanism operative in patients receiving massive transfusion has more than academic importance; it has direct implications for transfusion policy and practice.

References

Nov 1, 1992·The Journal of Trauma·T H Edna, T Bjerkeset
Aug 1, 1992·The American Review of Respiratory Disease·P J SloaneJ E Fish
Jul 1, 1989·The Journal of Trauma·T A GravesB A Pruitt
Aug 1, 1988·The British Journal of Surgery·P I Tartter
Aug 12, 1967·Lancet·D G AshbaughB E Levine
Oct 25, 1984·The New England Journal of Medicine·R L NicholsJ Mills
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·L D HudsonR J Maunder
Mar 1, 1994·American Journal of Respiratory Cell and Molecular Biology·R ShenkarE Abraham
Jan 1, 1994·Archives of Surgery·A SauaiaD C Lezotte
Feb 1, 1993·Archives of Surgery·N AgarwalW M Stahl
Apr 29, 1998·The Journal of Clinical Investigation·C C SillimanD R Ambruso
May 7, 1998·Transfusion Medicine·I Chin-YeeG Moses
Jan 27, 1999·Transfusion·T L DensmoreH Chaplin
Mar 24, 1999·The Journal of Trauma·M A CroceT J Gavin
Aug 10, 1999·American Journal of Clinical Pathology·S M DryR J Benjamin
Feb 12, 2000·Transfusion Medicine Reviews·S DzikE C Vamvakas
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Mar 13, 2001·Chest·J MilotF Maltais
Mar 14, 2001·Critical Care Medicine·A Tejada ArtigasA Hernández
Mar 22, 2001·Archives of Pathology & Laboratory Medicine·S E LenahanP J Romano
Apr 19, 2002·JAMA : the Journal of the American Medical Association·Patricia M KopkoMark A Popovsky
Feb 1, 2003·Transfusion·Grace S KaoRichard J Benjamin
Feb 21, 2003·The New England Journal of Medicine·Margaret S HerridgeUNKNOWN Canadian Critical Care Trials Group
Apr 12, 2003·Critical Care Medicine·Gordon D Rubenfeld
Apr 19, 2003·Transfusion·Christopher C SillimanNorbert F Voelkel
Jun 10, 2003·Critical Care Medicine·Christopher H GossUNKNOWN ARDS Network
Oct 22, 2003·Intensive Care Medicine·Christian Brun-BuissonUNKNOWN ALIVE Study Group
Mar 26, 2004·Human Immunology·Robert A BrayHoward M Gebel
Apr 29, 2004·Transfusion Medicine·A InsunzaV Hermosa

❮ Previous
Next ❯

Citations

Apr 24, 2013·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Emanuel V GeigerUNKNOWN TraumaRegister DGU®
Feb 15, 2011·Critical Care : the Official Journal of the Critical Care Forum·Pieter R TuinmanNicole P Juffermans
Oct 3, 2012·Proceedings of the American Thoracic Society·M Elizabeth WilcoxMargaret S Herridge
Apr 22, 2014·The Journal of Trauma and Acute Care Surgery·Takayuki OguraAlan T Lefor
Jul 26, 2014·Emergency Medicine Clinics of North America·Jessica L Osterman, Sanjay Arora
Aug 19, 2007·Journal of the Chinese Medical Association : JCMA·Jian-Ling ChenChin-Wang Chen
Sep 24, 2009·Critical Care Medicine·Lena M NapolitanoUNKNOWN Eastern Association for the Surgery of Trauma Practice Management Workgroup
Dec 20, 2007·Critical Care Medicine·Robert L ConhaimBruce A Harms
Oct 1, 2008·Critical Care Medicine·Paul E Marik, Howard L Corwin
Apr 25, 2008·Critical Care Medicine·Timothy R WatkinsAvery B Nathens
Oct 9, 2007·Obstetrics and Gynecology Clinics of North America·Andrea J Fuller, Brenda Bucklin
Apr 19, 2008·Acta Anaesthesiologica Scandinavica·Y Robinson
Apr 11, 2008·The Journal of Trauma·Daniel F McLaughlinJohn B Holcomb
Aug 15, 2008·Journal of Intensive Care Medicine·Kristen C Sihler, Lena M Napolitano
May 3, 2014·Intensive Care Medicine·Martin K WakehamMatthew C Scanlon
Jun 13, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Bhushan AsthanaRenu Saxena
May 23, 2012·The Journal of International Medical Research·H S ChungC S Park
May 23, 2008·Critical Care Medicine·Bradley D FreemanTimothy G Buchman
Nov 14, 2006·The Journal of Trauma·Yohan RobinsonAndreas Oberholzer
Jul 17, 2007·Pediatric Transplantation·Yoshihiro YuiTatsutoshi Nakahata
Aug 13, 2008·The Journal of Trauma·Jordan A WeinbergLoring W Rue
Sep 30, 2010·Scandinavian Journal of Medicine & Science in Sports·C EiraleH Chalabi
Apr 6, 2013·Critical Care : the Official Journal of the Critical Care Forum·Luciano C P AzevedoUNKNOWN ERICC (Epidemiology of Respiratory Insufficiency in Critical Care) investigators
Jul 25, 2012·Critical Care Medicine·Bradley D Freeman, Peter E Morris
Mar 10, 2011·Current Opinion in Anaesthesiology·Bradley D Freeman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved