Massive up-regulation of LBD transcription factors and EXPANSINs highlights the regulatory programs of rhizomania disease

Molecular Plant Pathology
Jose Fernando GilEugene I Savenkov

Abstract

Rhizomania of sugar beet, caused by Beet necrotic yellow vein virus (BNYVV), is characterized by excessive lateral root (LR) formation leading to dramatic reduction of taproot weight and massive yield losses. LR formation represents a developmental process tightly controlled by auxin signaling through AUX/IAA-ARF responsive module and LATERAL ORGAN BOUNDARIES DOMAIN (LBD) transcriptional network. Several LBD transcription factors play central roles in auxin-regulated LR development and act upstream of EXPANSINS (EXPs), cell wall (CW)-loosening proteins involved in plant development via disruption of the extracellular matrix for CW relaxation and expansion. Here, we present evidence that BNYVV hijacks these auxin-regulated pathways resulting in formation LR and root hairs (RH). We identified an AUX/IAA protein (BvAUX28) as interacting with P25, a viral virulence factor. Mutational analysis indicated that P25 interacts with domains I and II of BvAUX28. Subcellular localization of co-expressed P25 and BvAUX28 showed that P25 inhibits BvAUX28 nuclear localization. Moreover, root-specific LBDs and EXPs were greatly upregulated during rhizomania development. Based on these data, we present a model in which BNYVV P25 protein mimics ac...Continue Reading

References

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Citations

Apr 1, 2020·International Journal of Molecular Sciences·Yuwen ZhangXiangyuan Wan
May 16, 2020·International Journal of Molecular Sciences·Weimiao LiuJiashu Cao
Apr 4, 2019·Frontiers in Plant Science·Héctor H Torres-MartínezJoseph G Dubrovsky
Mar 24, 2021·The Plant Journal : for Cell and Molecular Biology·Xiuping ZouShanchun Chen
Aug 23, 2021·Molecular Plant Pathology·Maximilian MüllenderSebastian Liebe

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