Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects

The Journal of Clinical Endocrinology and Metabolism
M H RasmussenN E Skakkebae

Abstract

In the present study, we 1) determined whether the impaired spontaneous 24-h GH secretion as well as the blunted GH response to provocative testing in obese subjects are persistent disorders or transient defects reversed with weight loss and 2) investigated 24-h urinary GH excretion and basal levels of insulin-like growth factor-I (IGF-I), IGF-binding protein-3 (IGFBP-3), as well as insulin in obese subjects before and after a massive weight loss. We studied 18 obese subjects (age, 26 +/- 1 yr; body mass index, 40.9 +/- 1.1 kg/m2); 18 normal age-, and sex-matched control subjects; and 9 reduced weight obese subjects after a diet-induced average weight loss of 30.3 +/- 4.6 kg. Twenty-four-hour spontaneous GH secretion was estimated by obtaining 3240 integrated 20-min blood samples using a constant blood withdrawal technique and computerized algorithms. Body composition was determined using anthropometric measurements and dual energy x-ray absorptiometry scanning (DXA). In the obese subjects, 24-h spontaneous GH release profiles and the GH responses to insulin-induced hypoglycemia and L-arginine as well as basal IGF-I levels and the IGF-I/IGFBP-3 molar ratio were decreased, whereas insulin levels were elevated compared to those i...Continue Reading

Citations

May 31, 2012·Current Osteoporosis Reports·Alexander Faje, Anne Klibanski
Aug 10, 2011·International Journal of Endocrinology·Michael Højby RasmussenJannik Hilsted
Aug 18, 2012·International Journal of Endocrinology·Nigel Glynn, Amar Agha
Nov 15, 2012·Journal of Translational Medicine·Juan E Puche, Inma Castilla-Cortázar
Sep 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Hideo MakimuraSteven Grinspoon
May 28, 2009·The Journal of Clinical Endocrinology and Metabolism·J FrystykK K Miller
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Hideo MakimuraSteven K Grinspoon
Oct 15, 2010·The Journal of Clinical Endocrinology and Metabolism·Takara L StanleySteven K Grinspoon
Mar 31, 2011·Journal of Clinical Research in Pediatric Endocrinology·Kristin S OndrakJoanne S Harrell
Jul 2, 1998·Journal of Endocrinological Investigation·A ContiA Sartorio
Feb 23, 2013·Endocrine·Valéria Ernestânia ChavesGisele Lopes Bertolini
Dec 4, 2002·Clinical Endocrinology·Tom WhippleNancy Williams
Aug 5, 2015·Journal of Clinical Medicine·Marianne Klose, Ulla Feldt-Rasmussen
Apr 3, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maureen M J Guichelaar, Michael R Charlton
Nov 1, 2012·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·A SirbuS Fica
May 18, 2012·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M AndersenT L Nielsen
Dec 14, 2011·Domestic Animal Endocrinology·J Frystyk
Jan 7, 2016·Journal of Translational Medicine·G A AguirreI Castilla-Cortazar
Sep 3, 2009·Molecular and Cellular Endocrinology·Michael Højby Rasmussen
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Edith KoehlerMichael Charlton
Jun 6, 2013·Clinical Endocrinology·Ian W Seetho, John P H Wilding
Nov 3, 2009·Aging Cell·Leanne M RedmanUNKNOWN Pennington CALERIE Team
Dec 20, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Sanne Fisker
Sep 1, 1996·Endocrinology and Metabolism Clinics of North America·M E Geffner
Jan 9, 2004·Endocrinology and Metabolism Clinics of North America·Panagiotis Kokkoris, F Xavier Pi-Sunyer
Jun 2, 2015·Metabolism: Clinical and Experimental·Johannes D VeldhuisJean Wigham
Mar 11, 2015·Endocrine·Roberto Salvatori
Apr 23, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Marianne Andersen
May 3, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·H MakimuraS K Grinspoon
Jan 4, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Takara L Stanley, Steven K Grinspoon
Mar 16, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M KunitomiH Maknio
Jul 31, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M MaccarioE Ghigo
May 12, 2007·Pituitary·Mark Sherlock, Andrew A Toogood
Dec 24, 2018·American Journal of Physiology. Endocrinology and Metabolism·Morten Lyng HøgildJens O L Jørgensen
Jul 28, 2005·American Journal of Physiology. Endocrinology and Metabolism·Mette HansenKai Henrik Wiborg Lange
Aug 10, 2019·Hormone Molecular Biology and Clinical Investigation·Shereen M AleidiYasser Bustanji
Feb 4, 2005·Endocrine Reviews·Johannes D VeldhuisCyril Y Bowers
Nov 7, 2008·The Journal of Clinical Endocrinology and Metabolism·Gudmundur Johannsson

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