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Massively calcified endosomal death (MCED) of endothelial cells

bioRxiv

Jul 15, 2014

Larry Weisenthal

Abstract

We have discovered a novel and specific mechanism of endothelial cell death. We refer to this novel death mechanism as massively calcified endosomal death, or MCED. Exposure of endothelial cells to non-specific toxins or other physical stresses induces death by traditional apoptotic and...read more

Mentioned in this Paper

Exosomes
Tumor Cells, Uncertain Whether Benign or Malignant
Biochemical Pathway
Vascular Inflammations
Tumor Necrosis Factor-alpha
Angiogenic Process
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Pathogenic Organism
Inflammation Mediators
Toxin
3
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Massively calcified endosomal death (MCED) of endothelial cells

bioRxiv

Jul 15, 2014

Larry Weisenthal

PMID: 990007112

DOI: 10.1101/007112

Abstract

We have discovered a novel and specific mechanism of endothelial cell death. We refer to this novel death mechanism as massively calcified endosomal death, or MCED. Exposure of endothelial cells to non-specific toxins or other physical stresses induces death by traditional apoptotic and...read more

Mentioned in this Paper

Exosomes
Tumor Cells, Uncertain Whether Benign or Malignant
Biochemical Pathway
Vascular Inflammations
Tumor Necrosis Factor-alpha
Angiogenic Process
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Pathogenic Organism
Inflammation Mediators
Toxin
3

Similar Papers Found In These Feeds

Endocytic System

Adsorptive and receptor-mediated endocytosis via clathrin-coated vesicles provides the major and best-characterized portal for uptake of multiple molecules and particles into cells. Via clathrin-dependent endocytosis, cells receive nutrients, regulate receptors and other plasma membrane constituents, take up antigens, and remove senescent, excess, and potentially harmful substances from the extracellular fluid. Discover the latest research on endocytic system here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance

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Paper Details
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