Mast Cell Activation Disease and Microbiotic Interactions

Clinical Therapeutics
Lawrence B Afrin, Alexander Khoruts

Abstract

This article reviews the diagnostically challenging presentation of mast cell activation disease (MCAD) and current thoughts regarding interactions between microbiota and MCs. A search for all studies on interactions between mast cells, mast cell activation disease, and microbiota published on pubmed.gov and scholar.google.com between 1960 and 2015 was conducted using the search terms mast cell, mastocyte, mastocytosis, mast cell activation, mast cell activation disease, mast cell activation syndrome, microbiome, microbiota. A manual review of the references from identified studies was also conducted. Studies were excluded if they were not accessible electronically or by interlibrary loan. Research increasingly is revealing essential involvement of MCs in normal human biology and in human disease. Via many methods, normal MCs-present sparsely in every tissue-sense their environment and reactively exert influences that, directly and indirectly, locally and remotely, improve health. The dysfunctional MCs of the "iceberg" of MCAD, on the other hand, sense abnormally, react abnormally, activate constitutively, and sometimes (in mastocytosis, the "tip" of the MCAD iceberg) even proliferate neoplastically. MCAD causes chronic multisy...Continue Reading

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Citations

May 4, 2015·Clinical Therapeutics·Richard I Shader
Apr 25, 2020·Digestive Diseases and Sciences·Leonard B WeinstockGerhard J Molderings
Dec 5, 2018·Mediators of Inflammation·Claudio CostantiniLuigina Romani
May 10, 2019·Clinical Oral Investigations·Juliana Campos PinheiroPedro Paulo de Andrade Santos
Jul 30, 2020·Scientific Reports·Valentina ZamarianCristina Lecchi
Jul 25, 2021·International Journal of Molecular Sciences·Wonmin KoDong-Sung Lee

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