Mast cell activators as novel immune regulators

Current Opinion in Pharmacology
Brandi Johnson-WeaverHerman F Staats

Abstract

Mast cells are an important cell type of the innate immune system that when activated, play a crucial role in generating protective innate host responses after bacterial and viral infection. Additionally, activated mast cells influence lymph node composition to regulate the induction of adaptive immune responses. The recognition that mast cells play a beneficial role in host responses to microbial infection and induction of adaptive immunity has provided the rationale to evaluate mast cell activators for use as antimicrobials or vaccine adjuvants. This review summarizes the role of mast cell activators in antimicrobial responses while also discussing the use of different classes of mast cell activators as potent vaccine adjuvants that enhance the induction of protective immune responses.

Citations

Jan 18, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saptarshi RoyHydar Ali
Jun 25, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Mika Yamanaka-TakaichiDaisuke Tsuruta
Mar 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kinga Fanni TóthAttila Oláh
Feb 10, 2019·Cell Death and Differentiation·Nina GermicHans-Uwe Simon
Apr 29, 2020·Annual Review of Immunology·Stephen J GalliMindy Tsai

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