Mast cell chymase: morphofunctional characteristics

Histochemistry and Cell Biology
Dmitri AtiakshinMarkus Tiemann

Abstract

During degranulation, mast cells secrete a specific set of mediators defined as "secretome" including the preformed mediators that have already been synthesized by a cell and contained in the cytoplasmic granules. This group includes serine proteases, in particular, chymase and tryptase. Biological significance of chymase depends on the mechanisms of degranulation and is characterized by selective effects on the cellular and non-cellular components of the specific tissue microenvironment. Chymase is known to be closely involved in the mechanisms of inflammation and allergy, angiogenesis, and oncogenesis, remodeling of the extracellular matrix of the connective tissue and changes in organ histoarchitectonics. Number of chymase-positive mast cells in the intra-organ population, and the mechanisms of biogenesis and secretome degranulation appear to be the informative criteria for interpreting the state of the internal organs, characterizing not only the diagnostic efficacy but also the properties of targets of pharmacotherapy. In this review, we discussed the current state of knowledge about mast cell chymase as one of the mast cell secretome proteases. Main issues of the reviewed publications are highlighted with our microscopic ...Continue Reading

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Citations

Mar 31, 2020·Histochemistry and Cell Biology·Dmitri AtiakshinMarkus Tiemann
Jul 1, 2020·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth
Sep 27, 2019·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth
Oct 6, 2020·Immunity, Inflammation and Disease·Yukihisa InoueYasunari Miyazaki
May 1, 2021·Journal of Immunology Research·José Rodrigues do Carmo NetoMarcos Vinícius da Silva
Jun 3, 2021·International Journal of Molecular Sciences·Frida BerlinCecilia K Andersson
Feb 23, 2021··Dmitry A. Atiakshin, Viktoriya V. Shishkina

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